Intrapartum treatment of preeclamptic hypertension by ketanserin

Simple item page
dc.contributor.authorHulme V.A.
dc.contributor.authorOdendaal H.J.
dc.date.accessioned2011-05-15T16:15:21Z
dc.date.available2011-05-15T16:15:21Z
dc.date.issued1986
dc.description.abstractKetanserin was administered intravenously as either 20 or 10 mg boluses to 16 patients with severe preeclampsia in labor. The fetal heart rate was monitored with a scalp electrode and the uterine contractions were evaluated with a fluid-filled catheter connected to a physiologic pressure transducer. A 10-minute recording before every administration of ketanserin was compared to the same period immediately afterward. Ketanserin lowered the systolic and diastolic blood pressure significantly (p < 0.005, paired Student's t test). Maternal heart rate was unchanged but the mean fetal heart rate increased by 4.6 bpm. Long-term beat-to-beat variability and acceleration patterns were not affected. On four occasions an improvement in variable decelerations of the fetal heart, due to a reduction in uterine activity, was seen. Changes in the amplitude of contractions were not statistically significant. The freqency of contractions, however, was significantly reduced from 3.6 to 2.4 per 10 minutes (p < 0.005). No serious adverse effects occurred.
dc.description.versionArticle
dc.identifier.citationAmerican Journal of Obstetrics and Gynecology
dc.identifier.citation155
dc.identifier.citation2
dc.identifier.issn00029378
dc.identifier.urihttp://hdl.handle.net/10019.1/13302
dc.subjectketanserin
dc.subjectmagnesium sulfate
dc.subjectoxytocin
dc.subjectpethidine
dc.subjectadverse drug reaction
dc.subjectcardiovascular system
dc.subjectclinical article
dc.subjectdrowsiness
dc.subjectdrug efficacy
dc.subjectdrug therapy
dc.subjectfemale genital system
dc.subjectfetus
dc.subjectfetus heart rate
dc.subjectheart
dc.subjecthuman
dc.subjecthypertension
dc.subjectintravenous drug administration
dc.subjectlabor
dc.subjectmanagement
dc.subjectpreeclampsia
dc.subjectpregnancy
dc.subjectpriority journal
dc.subjectsouth africa
dc.subjecttherapy
dc.subjectuterus contractility
dc.subjectvertigo
dc.subjectBlood Pressure
dc.subjectFemale
dc.subjectFetal Heart
dc.subjectHeart Rate
dc.subjectHuman
dc.subjectHypertension
dc.subjectKetanserin
dc.subjectLabor Complications
dc.subjectPiperidines
dc.subjectPre-Eclampsia
dc.subjectPregnancy
dc.subjectUterine Contraction
dc.titleIntrapartum treatment of preeclamptic hypertension by ketanserin
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Tygerberg Hospital Publications