Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: potential scaffolds for estrogen receptor modulation and / or microtubule degradation

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dc.contributor.authorMabank, Tanyaen_ZA
dc.contributor.authorAlexandre, Kabamba B.en_ZA
dc.contributor.authorPelly, Stephen C.en_ZA
dc.contributor.authorGreen, Ivan R.en_ZA
dc.contributor.authorVan Otterlo, Willem A. L.en_ZA
dc.date.accessioned2021-11-10T12:15:33Z
dc.date.available2021-11-10T12:15:33Z
dc.date.issued2019
dc.descriptionCITATION: Mabank, T., et al. 2019. Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: potential scaffolds for estrogen receptor modulation and / or microtubule degradation. ARKIVOC, iv:245-279, doi:10.24820/ark.5550190.p010.962.
dc.descriptionThe original publication is available at https://www.arkat-usa.org/arkivoc-journal
dc.description.abstractENGLISH ABSTRACT: 6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds were evaluated for their ability to inhibit cell proliferation using the MCF7 (invasive ductal carcinoma) cell line.en_ZA
dc.description.urihttps://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/2019/4/
dc.description.versionPublisher's version
dc.format.extent35 pagesen_ZA
dc.identifier.citationMabank, T., et al. 2019. Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: potential scaffolds for estrogen receptor modulation and / or microtubule degradation. ARKIVOC, iv:245-279, doi:10.24820/ark.5550190.p010.962
dc.identifier.issn1551-7012 (online)
dc.identifier.otherdoi:10.24820/ark.5550190.p010.962
dc.identifier.urihttp://hdl.handle.net/10019.1/123417
dc.language.isoen_ZAen_ZA
dc.publisherARKAT USAen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subject6-Hydroxytetrahydroisoquinolinesen_ZA
dc.subjectEstrogen receptor modulators, Selectiveen_ZA
dc.subjectUrea industryen_ZA
dc.subjectThioureaen_ZA
dc.subjectSulfonamidesen_ZA
dc.titleSynthesis of 2-substituted tetrahydroisoquinolin-6-ols: potential scaffolds for estrogen receptor modulation and / or microtubule degradationen_ZA
dc.typeArticleen_ZA
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