Serum concentrations of some metals and steroids in patients with chronic fatigue syndrome with reference to neurological and cognitive abnormalities

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dc.contributor.authorVan Rensburg S.J.
dc.contributor.authorPotocnik F.C.V.
dc.contributor.authorKiss T.
dc.contributor.authorHugo F.
dc.contributor.authorVan Zijl P.
dc.contributor.authorMansvelt E.
dc.contributor.authorCarstens M.E.
dc.contributor.authorTheodorou P.
dc.contributor.authorHurly P.R.
dc.contributor.authorEmsley R.A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:15:45Z
dc.date.available2011-05-15T16:15:45Z
dc.date.issued2001
dc.description.abstractChronic fatigue syndrome is defined by the Atlanta Centers for Disease Control (Atlanta, GA, USA) as debilitating fatigue lasting for longer than 6 months. Symptoms include disturbances of cognition. Certain factors have in the past been shown to influence cognition, including metals such as aluminum, iron, and zinc; and steroids such as dehydroepiandrosterone. In the present study, concentrations of these factors were determined in the serum and plasma of patients and their age- and gender-matched healthy controls (10 women and 5 men in each group). In addition, copper, dehydroepiandrosterone sulphate, cortisol, cholesterol, hemoglobin, ferritin and transferrin concentrations, as well as transferrin genetic subtypes were determined in both groups. The results indicate that patients had significantly increased serum aluminum and decreased iron compared to controls. In the females, serum iron and dehydroepiandrosterone sulphate were significantly decreased and correlated. Total cholesterol was significantly increased, and significantly negatively correlated with dehydroepiandrosterone sulphate. There were no differences in zinc, copper, cortisol, hemoglobin, transferrin and ferritin concentrations, or in transferrin genetic subtypes. © 2001 Elsevier Science Inc.
dc.description.versionConference Paper
dc.identifier.citationBrain Research Bulletin
dc.identifier.citation55
dc.identifier.citation2
dc.identifier.issn03619230
dc.identifier.other10.1016/S0361-9230(01)00478-6
dc.identifier.urihttp://hdl.handle.net/10019.1/13472
dc.subjectaluminum
dc.subjecthemoglobin
dc.subjecthydrocortisone
dc.subjectprasterone sulfate
dc.subjectcholesterol blood level
dc.subjectchronic fatigue syndrome
dc.subjectclinical article
dc.subjectcognitive defect
dc.subjectconference paper
dc.subjectcontrolled study
dc.subjectcopper blood level
dc.subjectfemale
dc.subjectferritin blood level
dc.subjecthuman
dc.subjecthydrocortisone blood level
dc.subjectiron blood level
dc.subjectmale
dc.subjectpriority journal
dc.subjectsteroid blood level
dc.subjecttransferrin blood level
dc.subjectAdult
dc.subjectAluminum
dc.subjectBinding, Competitive
dc.subjectCholesterol
dc.subjectCognition Disorders
dc.subjectCopper
dc.subjectDehydroepiandrosterone
dc.subjectDehydroepiandrosterone Sulfate
dc.subjectFatigue Syndrome, Chronic
dc.subjectFemale
dc.subjectFerritins
dc.subjectGene Frequency
dc.subjectHemoglobins
dc.subjectHumans
dc.subjectHydrocortisone
dc.subjectIron
dc.subjectMale
dc.subjectMetals
dc.subjectSex Factors
dc.subjectSteroids
dc.subjectTransferrin
dc.subjectZinc
dc.titleSerum concentrations of some metals and steroids in patients with chronic fatigue syndrome with reference to neurological and cognitive abnormalities
dc.typeConference Paper
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