Bone mineral density in long-term survivors of childhood cancer
dc.contributor.author | Hesseling P.B. | |
dc.contributor.author | Hough S.F. | |
dc.contributor.author | Nel E.D. | |
dc.contributor.author | Van Riet F.A. | |
dc.contributor.author | Beneke T. | |
dc.date.accessioned | 2011-05-15T16:16:39Z | |
dc.date.available | 2011-05-15T16:16:39Z | |
dc.date.issued | 1998 | |
dc.description.abstract | Bone mineral density (BMD) of the lumbar spine was measured in 97 long-term survivors of childhood cancer 5-23 years after diagnosis using dual-energy X-ray absorptiometry (DXA). They had been treated for acute leukemia (n = 22), brain tumors (n = 16), lymphomas (n = 16), Wilms' tumor (n = 10), neuroblastoma (n = 7) and other cancers (n = 26). The correlations between BMD and the Z-scores for weight for height, height for age and weight for age at diagnosis and follow-up were evaluated with stepwise multiple regression. Correlations with cumulative corticosteroid and radiation dose were examined with Spearman's correlation coefficient. The number and nature of fractures were noted. A BMD Z-score of below -2 was present in 13 and a BMD Z-score of - I to -2 in 31 children. In total, a low BMD was observed in 45% of children. Height for age at follow-up correlated significantly with BMD Z-score. Increasing doses of cranial irradiation (18-54 Gy) were associated with lower BMD (p = 0.001, Spearman). This was true also for 22 children with acute lymphoblastic leukemia (ALL) who had received 18-24 Gy cranial irradiation (p = 0.04, Spearman). Fractures occurred in 14 children following trauma. The difference in BMD Z-scores of children with and without fractures did not achieve statistical significance although the majority of the children with fractures had low BMD Z-scores. The significant inverse correlation between height for age at follow-up and BMD must be interpreted with the realization that DXA is not a volumetric measurement of BMD and that short stature is associated with a smaller skeletal mass. © 1998 Wiley-Liss, Inc. | |
dc.description.version | Article | |
dc.identifier.citation | International Journal of Cancer | |
dc.identifier.citation | 78 | |
dc.identifier.citation | SUPPL. 11 | |
dc.identifier.issn | 00207136 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/13876 | |
dc.subject | corticosteroid | |
dc.subject | antineoplastic agent | |
dc.subject | analysis of variance | |
dc.subject | article | |
dc.subject | body weight | |
dc.subject | bone density | |
dc.subject | child | |
dc.subject | cross-sectional study | |
dc.subject | female | |
dc.subject | fracture | |
dc.subject | human | |
dc.subject | male | |
dc.subject | multimodality cancer therapy | |
dc.subject | neoplasm | |
dc.subject | pathophysiology | |
dc.subject | radiodensitometry | |
dc.subject | regression analysis | |
dc.subject | risk factor | |
dc.subject | skull irradiation | |
dc.subject | survivor | |
dc.subject | acute lymphoblastic leukemia | |
dc.subject | bone mineral | |
dc.subject | brain tumor | |
dc.subject | cancer survival | |
dc.subject | childhood cancer | |
dc.subject | conference paper | |
dc.subject | dual energy X ray absorptiometry | |
dc.subject | lumbar spine | |
dc.subject | lymphoma | |
dc.subject | major clinical study | |
dc.subject | nephroblastoma | |
dc.subject | neuroblastoma | |
dc.subject | priority journal | |
dc.subject | Adrenal Cortex Hormones | |
dc.subject | Analysis of Variance | |
dc.subject | Body Weight | |
dc.subject | Bone Density | |
dc.subject | Child | |
dc.subject | Combined Modality Therapy | |
dc.subject | Cranial Irradiation | |
dc.subject | Cross-Sectional Studies | |
dc.subject | Densitometry, X-Ray | |
dc.subject | Female | |
dc.subject | Fractures, Bone | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Neoplasms | |
dc.subject | Regression Analysis | |
dc.subject | Risk Factors | |
dc.subject | Survivors | |
dc.title | Bone mineral density in long-term survivors of childhood cancer | |
dc.type | Article |