Evaluating the probability of silent circulation of polio in small populations using the silent circulation statistic

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dc.contributor.authorVallejo, Celesteen_ZA
dc.contributor.authorPearson, Carl A. B.en_ZA
dc.contributor.authorKoopman, Jamesen_ZA
dc.contributor.authorHladish, Thomas J.en_ZA
dc.date.accessioned2021-10-25T09:10:08Z
dc.date.available2021-10-25T09:10:08Z
dc.date.issued2019
dc.descriptionCITATION: Vallejo, C., et al. 2019. Evaluating the probability of silent circulation of polio in small populations using the silent circulation statistic,Infectious Disease Modelling, 4:239-250, doi:10.1016/j.idm.2019.06.003.
dc.descriptionThe original publication is available at https://www.sciencedirect.com
dc.description.abstractAs polio-endemic countries move towards elimination, infrequent first infections and incomplete surveillance make it difficult to determine when the virus has been eliminated from the population. Eichner and Dietz [American Journal of Epidemiology, 143, 8 (1996)] proposed a model to estimate the probability of silent polio circulation depending upon when the last paralytic case was detected. Using the same kind of stochastic model they did, we additionally model waning polio immunity in the context of isolated, small, and unvaccinated populations. We compare using the Eichner and Dietz assumption of an initial case at the start of the simulation to a more accurate determination that observes the first case. The former estimates a higher probability of silent circulation in small populations, but this effect diminishes with increasing model population. We also show that stopping the simulation after a specific time estimates a lower probability of silent circulation than when all replicates are run to extinction, though this has limited impact on small populations. Our extensions to the Eichner and Dietz work improve the basis for decisions concerning the probability of silent circulation. Further model realism will be needed for accurate silent circulation risk assessment.en_ZA
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S2468042719300041?via%3Dihub
dc.description.versionPublisher's version
dc.format.extent12 pages
dc.identifier.citationVallejo, C., et al. 2019. Evaluating the probability of silent circulation of polio in small populations using the silent circulation statistic,Infectious Disease Modelling, 4:239-250, doi:10.1016/j.idm.2019.06.003
dc.identifier.issn1559-2448 (online)
dc.identifier.issn1096-7508 (print)
dc.identifier.otherdoi:10.1016/j.idm.2019.06.003
dc.identifier.urihttp://hdl.handle.net/10019.1/123301
dc.language.isoen_ZAen_ZA
dc.publisherKeAi Communications
dc.rights.holderAuthors retain copyright
dc.subjectSilent circulation of poliomyelitis -- Statisticsen_ZA
dc.subjectPoliomyelitis -- Infections -- Mathematical modelsen_ZA
dc.subjectPoliomyelitis -- Transmission -- Mathematical modelsen_ZA
dc.titleEvaluating the probability of silent circulation of polio in small populations using the silent circulation statisticen_ZA
dc.typeArticleen_ZA
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