Linkage disequilibrium between a marker on the low-density lipoprotein receptor and high cholesterol levels

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dc.contributor.authorBrink, P. A.en_ZA
dc.contributor.authorSteyn, L. T.en_ZA
dc.contributor.authorBester, A. J.en_ZA
dc.contributor.authorSteyn, K.en_ZA
dc.date.accessioned2011-03-18T14:59:40Z
dc.date.available2011-03-18T14:59:40Z
dc.date.issued1986-07en_ZA
dc.descriptionPlease cite as follows: Brink, P. A., Steyn, L. T., Bester, A. J. & Steyn, K. 1986. Linkage disequilibrium between a marker on the low-density lipoprotein receptor and high cholesterol levels. South African Medical Journal, 70:80-82.en_ZA
dc.descriptionThe original publication is available at http://www.samj.org.zaen_ZA
dc.description.abstractWe describe the presence of a linkage disequilibrium between high cholesterol levels in Afrikaner individuals and the common allele of the Pvu II restriction fragment polymorphism on the low-density lipoprotein (LDL) receptor gene. The frequencies of the common and the rare allele in a sample of the Afrikaner population were 0,654 and 0,346 (65 individuals) and 0,794 and 0,206 in the hypercholesterolaemic population (34 patients) (P < 0,05). This finding supports other evidence for a founder origin of the high frequency of familial hypercholesterolaemia among Afrikaners.en_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extentpages 80-82
dc.identifier.citationBrink, P. A., Steyn, L. T., Bester, A. J. & Steyn, K. 1986. Linkage disequilibrium between a marker on the low-density lipoprotein receptor and high cholesterol levels. South African Medical Journal, 70:80-82.en_ZA
dc.identifier.issn2078-5135 (online)en_ZA
dc.identifier.issn0256-9574 (print)en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/7971
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectLow density lipoproteinsen_ZA
dc.subjectBlood cholesterolen_ZA
dc.subjectLinkage (Genetics)en_ZA
dc.subjectHuman cellsen_ZA
dc.subjectHypercholesteremiaen_ZA
dc.titleLinkage disequilibrium between a marker on the low-density lipoprotein receptor and high cholesterol levelsen_ZA
dc.typeArticleen_ZA
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