Effect of non-tuberculous mycobacteria on host biomarkers potentially relevant for tuberculosis management

Simple item page
dc.contributor.authorDhanasekaran, S.en_ZA
dc.contributor.authorJenum, Synneen_ZA
dc.contributor.authorStavrum, Ruthen_ZA
dc.contributor.authorWiker, Harald G.en_ZA
dc.contributor.authorKenneth, Johnen_ZA
dc.contributor.authorVaz, Marioen_ZA
dc.contributor.authorDoherty, T. Marken_ZA
dc.contributor.authorGrewal, Harleen M. S.en_ZA
dc.contributor.authorHesseling, A. C.en_ZA
dc.date.accessioned2016-03-09T12:42:08Z
dc.date.available2016-03-09T12:42:08Z
dc.date.issued2014-10-16
dc.descriptionPlease cite as follows: Dhanasekaran, S. et al. 2014. Effect of non-tuberculous mycobacteria on host biomarkers potentially relevant for tuberculosis management. PLoS Neglected Tropical Diseases, 8(10):e3243., doi:10.1371/journal.pntd.0003243.en_ZA
dc.descriptionThe original publication is available at http://journals.plos.org/plosntdsen_ZA
dc.description.abstractBackground: Non-tuberculous mycobacteria (NTM) are different from Mycobacterium tuberculosis (MTB) both in their ubiquitous environmental distribution and in their reduced capacity to cause disease. While often neglected in favour of other infectious diseases, NTM may interfere with important aspects of TB control and management, namely the efficacy of new anti-tuberculosis (TB) vaccines; the immuno-diagnostic Tuberculin skin test (TST) and QuantiFERON TB Gold In Tube assay (QFTGIT); and immune biomarkers explored for their diagnostic and/or predictive potential. Our objective was therefore to explore host immune biomarkers in children who had NTM isolated from respiratory and/or gastric specimens. Methodology and Principle Findings: The present study was nested within a prospective cohort study of BCG-vaccinated neonates in Southern India. In this setting, immune biomarkers from peripheral blood were analyzed in 210 children aged , 3 years evaluated for TB using dual-colour-Reverse-Transcriptase-Multiple-Ligation-dependent-Probe-Amplification (dcRTMLPA) and Bio-Plex assays. The children were classified based on clinical examination, chest X-rays and mycobacterial culture reports as either: 1) TB disease, 2) NTM present and 3) controls. The study shows a down-regulation of RAB33A (p, 0.001) and up-regulation of TGFb1, IL-2 and IL-6 (all p,0.05) in children with TB disease, and that RAB33A, TGFBR2 and IL-10 (all p,0.05) were differentially expressed in children with NTM present when compared to children that were culture negative for MTB and NTM (controls). Conclusions and Significance: Carriage of NTM may reduce the specificity of future diagnostic and predictive immune biomarkers relevant to TB management.en_ZA
dc.description.urihttp://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003243
dc.description.versionPublisher's versionen_ZA
dc.format.extent9 pagesen_ZA
dc.identifier.citationDhanasekaran, S. et al. 2014. Effect of non-tuberculous mycobacteria on host biomarkers potentially relevant for tuberculosis management. PLoS Neglected Tropical Diseases, 8(10):e3243., doi:10.1371/journal.pntd.0003243.en_ZA
dc.identifier.issn1935-2735 (online)
dc.identifier.otherdoi:10.1371/journal.pntd.0003243
dc.identifier.urihttp://hdl.handle.net/10019.1/98271
dc.language.isoen_ZAen_ZA
dc.publisherPLoSen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectMycobacterial diseasesen_ZA
dc.subjectTuberculosis -- Preventionen_ZA
dc.titleEffect of non-tuberculous mycobacteria on host biomarkers potentially relevant for tuberculosis managementen_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
dhanasekaran_effect_2014.pdf
Size:
1.99 MB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.95 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Desmond Tutu TB Centre)