Comparison of the lytic effects of four prostaglandin analogues in the chacma baboon (Papio ursinus ursinus)

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dc.contributor.authorRall H.J.S.
dc.contributor.authorZuurmond T.J.
dc.contributor.authorWeidemann A.
dc.date.accessioned2011-05-15T16:16:40Z
dc.date.available2011-05-15T16:16:40Z
dc.date.issued1979
dc.description.abstractSix healthy, cycling female chacma baboons (Papio ursinus ursinus) were used to determine the luteolytic effects of four prostaglandin analogues. The compounds were administered according to a study design which made provision for adequate controls. Five to seven days following ovulation, venous blood was collected and the baboon given a single intramuscular injection of a compound at a recommended dose. Blood was then collected serially every 3 hr for three samples and again at 24, 48, and 72 hr to determine the continued effect of the prostaglandin analogues on corpus luteum production of progesterone. It was found that PGF(2α)-1,15-lactone, 11α(15S)-17-phenyl-18,19,20-trinor-ent-PGE2 methyl ester and 17-phenyl-18,19,20-trinor-PGF(2α) exhibited definite luteolytic potential in this species. Equivocal results were obtained with (15S)-15-methyl-PGF(2α) THAM and its toxic qualities resulted in the demise of three animals.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Fertility
dc.identifier.citation24
dc.identifier.citation1
dc.identifier.issn0020725X
dc.identifier.urihttp://hdl.handle.net/10019.1/13883
dc.subjectcarboprost trometamol
dc.subjectplacebo
dc.subjectprogesterone
dc.subjectprostaglandin derivative
dc.subjectprostaglandin receptor
dc.subjectu32921e
dc.subjectu35687
dc.subjectu43728
dc.subjectu47473
dc.subjectunclassified drug
dc.subject17 phenyl 18,19,20 trinorprostaglandin e2 methyl ester
dc.subject17 phenyl 18,19,20 trinorprostaglandin f2 alpha
dc.subjectanimal experiment
dc.subjectbaboon
dc.subjectdrug comparison
dc.subjectfemale genital system
dc.subjectintramuscular drug administration
dc.subjectluteolysis
dc.subjectmonkey
dc.subjectprostaglandin f2 alpha lactone
dc.subjectAnimal
dc.subjectComparative Study
dc.subjectDrug Evaluation, Preclinical
dc.subjectFemale
dc.subjectHaplorhini
dc.subjectInjections, Intramuscular
dc.subjectLuteolytic Agents
dc.subjectPapio
dc.subjectProgesterone
dc.subjectProstaglandins E, Synthetic
dc.subjectProstaglandins F, Synthetic
dc.titleComparison of the lytic effects of four prostaglandin analogues in the chacma baboon (Papio ursinus ursinus)
dc.typeArticle
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