An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet

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dc.contributor.authorRengan, A. K.en_ZA
dc.contributor.authorAgarwal, A.en_ZA
dc.contributor.authorVan der Linde, M.en_ZA
dc.contributor.authorDu Plessis, S. S.en_ZA
dc.date.accessioned2013-02-14T06:34:17Z
dc.date.available2013-02-14T06:34:17Z
dc.date.issued2012-11-17
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.en_ZA
dc.descriptionThe original publication is available at http://www.rbej.com/contenten_ZA
dc.description.abstractRecent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may transpire. The cytoplasmic droplet then becomes known as excess residual cytoplasm, which can impair overall sperm function and produce higher levels of reactive oxygen species, potentially leading to male infertility. Though the distinction between cytoplasmic droplets and excess residual cytoplasm has been made, some studies fail to recognize the difference and incorrectly label the latter as a cytoplasmic droplet. This review attempts to clarify excess residual cytoplasm’s effect on fertility, examine the enzymes responsible, and suggest tests and possible treatment options for those affected by this defect.en_ZA
dc.description.sponsorshipStellenbosch Universityen_ZA
dc.description.versionPublishers' versionen_ZA
dc.identifier.citationRengan, A. K., Agarwal, A., van der Linde, M. & du Plessis, S. S. 2012. An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet. Reproductive biology and endocrinology, 10, doi:10.1186/1477-7827-10-92.en_ZA
dc.identifier.issn1477-7827 (print)
dc.identifier.issn1477-7827 (online)
dc.identifier.otherdoi:10.1186/1477-7827-10-92
dc.identifier.urihttp://hdl.handle.net/10019.1/79357
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Cenralen_ZA
dc.rights.holderAuthor retain copyrighten_ZA
dc.subjectCytoplasmic dropleten_ZA
dc.subjectExcess residual cytoplasmen_ZA
dc.subjectMidpieceen_ZA
dc.subjectSpermiogenesisen_ZA
dc.subjectCytoplasmic extrusionen_ZA
dc.subjectResidual bodyen_ZA
dc.subjectRegulatory volume decreaseen_ZA
dc.subjectReactive oxygen speciesen_ZA
dc.subjectOxidative stressen_ZA
dc.subjectPeroxidative damageen_ZA
dc.titleAn investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic dropleten_ZA
dc.typeArticleen_ZA
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