Detection of biological false positive syphilis serum reactions

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dc.contributor.authorBrede, H. D.en_ZA
dc.contributor.authorWilley, K. D. F.en_ZA
dc.contributor.authorKindermann, R. A.en_ZA
dc.contributor.authorFinlayson, M. H.en_ZA
dc.date.accessioned2011-03-18T14:57:57Z
dc.date.available2011-03-18T14:57:57Z
dc.date.issued1974
dc.descriptionCITATION: Brede, H. D., et al. 1974. Detection of biological false positive syphilis serum reactions. South African Medical Journal, 48(28):1191-1194.
dc.descriptionThe original publication is available at https://journals.co.za
dc.description.abstractA comparative evaluation of reagin tests (Wassermann, VDRL, RPR) and fluorescent treponema antibody absorption tests (FTA ABS) performed on blood specimens from 5,271 persons (2,493 pregnant women, 1,130 apparently healthy prospective employees, 1,345 newborn babies and 303 leprosy patients) showed that 17.2% of the pregnant women, 11.95% of the prospective employees, 19.0% of the newborn babies, and 27.2% of the leprosy patients gave positive reactions in one or more of the tests. The majority of specimens were from Cape Colored patients. FTA ABS tests allowed the exclusion as biological false positives of ± 30% of the pregnant 'positive reactors', of ± 37% of the prospective employees, 40.2% of the newborn babies, but only 1% of the leprosy patients. The FTA ABS test, therefore, deserves wide acceptance as the standard by which the diagnosis of syphilis is confirmed and false positive reactions are defined, although non specificity in pregnancies, intracellular infections and auto immune diseases occurs. The classical reagin tests are of value in the control of treatment.
dc.description.urihttps://journals.co.za/content/m_samj/48/28/AJA20785135_27074
dc.description.versionPublisher’s version
dc.identifier.citationBrede, H. D., et al. 1974. Detection of biological false positive syphilis serum reactions. South African Medical Journal, 48(28):1191-1194
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7760
dc.language.isoenen_ZA
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectSyphilis -- Diagnosis -- Wassermann reaction
dc.subjectImmunology
dc.subjectMicrobiology
dc.titleDetection of biological false positive syphilis serum reactionsen_ZA
dc.typeArticle
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