Treatment of Heterogeneous Emphysema Using the Spiration IBV Valves

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dc.contributor.authorSpringmeyer S.C.
dc.contributor.authorBolliger C.T.
dc.contributor.authorWaddell T.K.
dc.contributor.authorGonzalez X.
dc.contributor.authorWood D.E.
dc.date.accessioned2011-05-15T16:18:13Z
dc.date.available2011-05-15T16:18:13Z
dc.date.issued2009
dc.description.abstractNinety-eight emphysema patients were treated at 13 international sites during a 3-year series of single-arm, open-label studies with the IBV valve and a multi-lobar treatment approach. Fifty six percent of subjects had a clinically meaningful improvement in health-related quality of life, but standard pulmonary function and exercise studies were insensitive effectiveness measures. Quantitative CT analyses of regional lung changes showed lobar volume changes in over 85% of subjects. Lung volume reduction was an uncommon mechanism for a treatment response with bilateral upper lobe treatment. A redirection of inspired air, an interlobar shift to healthier lung tissue, was the most common mechanism for a valve treatment response. © 2009 Elsevier Inc. All rights reserved.
dc.description.versionReview
dc.identifier.citationThoracic Surgery Clinics
dc.identifier.citation19
dc.identifier.citation2
dc.identifier.issn15474127
dc.identifier.other10.1016/j.thorsurg.2009.02.005
dc.identifier.urihttp://hdl.handle.net/10019.1/14560
dc.subjectadult
dc.subjectaged
dc.subjectatelectasis
dc.subjectbronchospasm
dc.subjectclinical effectiveness
dc.subjectclinical trial
dc.subjectcohort analysis
dc.subjectcomputer assisted tomography
dc.subjectcontrolled study
dc.subjectemphysema
dc.subjectexercise
dc.subjectfemale
dc.subjectheart arrest
dc.subjectheart infarction
dc.subjectheterogeneous emphysema
dc.subjecthospitalization
dc.subjecthuman
dc.subjectinspiratory capacity
dc.subjectlung function
dc.subjectlung lobe
dc.subjectlung parenchyma
dc.subjectlung resection
dc.subjectlung volume
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmulticenter study
dc.subjectopen study
dc.subjectpneumothorax
dc.subjectpriority journal
dc.subjectprosthesis
dc.subjectquality of life
dc.subjectquantitative analysis
dc.subjectrespiratory distress
dc.subjectreview
dc.subjectspiration IBV valve
dc.subjectsurgical approach
dc.subjectthorax pain
dc.subjecttreatment outcome
dc.subjecttreatment response
dc.subjectAged
dc.subjectBronchoscopy
dc.subjectCohort Studies
dc.subjectEquipment Design
dc.subjectExercise Tolerance
dc.subjectFemale
dc.subjectForced Expiratory Volume
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPneumonectomy
dc.subjectPulmonary Emphysema
dc.subjectRetrospective Studies
dc.subjectTreatment Outcome
dc.titleTreatment of Heterogeneous Emphysema Using the Spiration IBV Valves
dc.typeReview
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