Child contact management in high tuberculosis burden countries : a mixed-methods systematic review

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dc.contributor.authorSzkwarko, Dariaen_ZA
dc.contributor.authorHirsch-Moverman, Yaelen_ZA
dc.contributor.authorDu Plessis, Lienkien_ZA
dc.contributor.authorDu Preez, Karenen_ZA
dc.contributor.authorCar, Catherineen_ZA
dc.contributor.authorMandalakas, Anna M.en_ZA
dc.date.accessioned2018-11-12T14:15:31Z
dc.date.available2018-11-12T14:15:31Z
dc.date.issued2017-03-08
dc.descriptionCITATION: Szkwarko, D., et al. 2017. Child contact management in high tuberculosis burden countries : a mixed-methods systematic review. PLoS ONE, 12(8):e0182185, doi:10.1371/journal.pone.0182185.
dc.descriptionThe original publication is available at https://journals.plos.org/plosone
dc.description.abstractENGLISH Abstract: Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide. Considering the World Health Organization recommendation to implement child contact management (CCM) for TB, we conducted a mixed-methods systematic review to summarize CCM implementation, challenges, predictors, and recommendations. We searched the electronic databases of PubMed/MEDLINE, Scopus, and Web of Science for studies published between 1996–2017 that reported CCM data from high TB-burden countries. Protocol details for this systematic review were registered on PROSPERO: International prospective register of systematic reviews (#CRD42016038105). We formulated a search strategy to identify all available studies, published in English that specifically targeted a) population: child contacts (<15 years) exposed to TB in the household from programmatic settings in high burden countries (HBCs), b) interventions: CCM strategies implemented within the CCM cascade, c) comparisons: CCM strategies studied and compared in HBCs, and d) outcomes: monitoring and evaluation of CCM outcomes reported in the literature for each CCM cascade step. We included any quantitative, qualitative, mixed-methods study design except for randomized-controlled trials, editorials or commentaries. Thirty-seven studies were reviewed. Child contact losses varied greatly for screening, isoniazid preventive therapy initiation, and completion. CCM challenges included: infrastructure, knowledge, attitudes, stigma, access, competing priorities, and treatment. CCM recommendations included: health system strengthening, health education, and improved preventive therapy. Identified predictors included: index case and clinic characteristics, perceptions of barriers and risk, costs, and treatment characteristics. CCM lacks standardization resulting in common challenges and losses throughout the CCM cascade. Prioritization of a CCM-friendly healthcare environment with improved CCM processes and tools; health education; and active, evidence-based strategies can decrease barriers. A focused approach toward every aspect of the CCM cascade will likely diminish losses throughout the CCM cascade and ultimately decrease TB related morbidity and mortality in children.en_ZA
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182185
dc.description.versionPublisher's version
dc.format.extent23 pages : illustrationsen_ZA
dc.identifier.citationSzkwarko, D., et al. 2017. Child contact management in high tuberculosis burden countries : a mixed-methods systematic review. PLoS ONE, 12(8):e0182185, doi:10.1371/journal.pone.0182185
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0182185
dc.identifier.urihttp://hdl.handle.net/10019.1/104678
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTuberculosis -- Diagnosisen_ZA
dc.subjectTuberculosis researchen_ZA
dc.subjectTuberculosis in childrenen_ZA
dc.titleChild contact management in high tuberculosis burden countries : a mixed-methods systematic reviewen_ZA
dc.typeArticleen_ZA
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