Effect of medroxyprogesterone acetate contraception on cytoplasmic estrogen receptor content of the human cervix uteri

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dc.contributor.authorRall H.J.S.
dc.contributor.authorSoto Ferreira G.
dc.contributor.authorJanssens K.Y.
dc.date.accessioned2011-05-15T16:16:40Z
dc.date.available2011-05-15T16:16:40Z
dc.date.issued1978
dc.description.abstractSpecimens of cervical tissue from 5 women each on 150 mg and 450 mg regimens of medroxyprogesterone acetate (MPA) for contraceptive purposes, were obtained through punch biopsy 15 days after injection. In another group of 5 women each on the same contraceptive regimens, punch biopsies of the cervix uteri were obtained 30 days after injection. These times corresponded to maximum and optimum blood levels of MPA respectively. Corresponding tissue from the same anatomical position in patients matched, where possible, for age and parity was obtained from hysterectomy specimens to serve as controls. Quantification of estrogen receptor content in the cytoplasm of these tissues was achieved through standard procedures. Analysis of data showed that MPA suppressed estrogen receptor content significantly compared to controls, but that there were no differences in this effect between the 2 dosages or time of biopsy.The effect of medroxyprogesterone acetate (MPA) contraception on cytoplasmic estrogen receptor content of the human cervix uteri was investigated. Cervical specimens from 5 women each on 150 mg and 450 mg regimens of MPA were obtained through punch biopsy 15 days postinjection. In another similar group of 5 women, specimens were obtained 30 days postinjection. These times corresponded to maximum and optimum blood levels of MPA, respectively. Corresponding tissue from hysterectomy specimens served as controls. Quantification of estrogen receptor content in the cytoplasm was achieved through standard procedures. There was a highly significant difference (p .000001) between the MPA treated and control groups; the mean femtomole values were 120.6 and 271.39, respectively. These results are indicative of drastic suppression of estrogen receptors by MPA. No differences between the 2 dosage regimens or time of biopsy were found in regard to this effect.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Fertility
dc.identifier.citation23
dc.identifier.citation1
dc.identifier.issn0020725X
dc.identifier.urihttp://hdl.handle.net/10019.1/13884
dc.subjectdrug receptor
dc.subjectestrogen receptor
dc.subjectmedroxyprogesterone acetate
dc.subjectanimal experiment
dc.subjectcontraception
dc.subjectcytology
dc.subjectdose response
dc.subjectdrug response
dc.subjectestrogen therapy
dc.subjectfemale genital system
dc.subjecthistology
dc.subjectintramuscular drug administration
dc.subjectparenteral drug administration
dc.subjectpharmacokinetics
dc.subjectuterine cervix
dc.subjectAge Factors
dc.subjectBiology
dc.subjectCervical Effects
dc.subjectCervix
dc.subjectClinical Research
dc.subjectContraception
dc.subjectContraceptive Agents, Female--administraction and dosage
dc.subjectContraceptive Agents, Female--side effects
dc.subjectContraceptive Agents, Progestin--administraction and dosage
dc.subjectContraceptive Agents, Progestin--side effects
dc.subjectContraceptive Agents--administraction and dosage
dc.subjectContraceptive Agents--side effects
dc.subjectDemographic Factors
dc.subjectExaminations And Diagnoses
dc.subjectFamily Planning
dc.subjectFertility
dc.subjectFertility Measurements
dc.subjectGenitalia
dc.subjectGenitalia, Female
dc.subjectHormone Receptors
dc.subjectInjectables
dc.subjectLaboratory Examinations And Diagnoses
dc.subjectLaboratory Procedures
dc.subjectMedroxyprogesterone Acetate--administraction and dosage
dc.subjectMedroxyprogesterone Acetate--side effects
dc.subjectMembrane Proteins
dc.subjectParity
dc.subjectPhysiology
dc.subjectPopulation
dc.subjectPopulation Characteristics
dc.subjectPopulation Dynamics
dc.subjectResearch Methodology
dc.subjectUrogenital System
dc.subjectUterus
dc.subjectWomen
dc.subjectAdult
dc.subjectCervix Uteri
dc.subjectComparative Study
dc.subjectCytoplasm
dc.subjectFemale
dc.subjectHuman
dc.subjectHysterectomy
dc.subjectMedroxyprogesterone
dc.subjectMiddle Age
dc.subjectParity
dc.subjectPregnancy
dc.subjectReceptors, Estrogen
dc.subjectTime Factors
dc.titleEffect of medroxyprogesterone acetate contraception on cytoplasmic estrogen receptor content of the human cervix uteri
dc.typeArticle
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