Comparison of antiretroviral therapy adherence among HIV-infected older adults with younger adults in Africa : systematic review and meta-analysis

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dc.contributor.authorSoomro, Najeebullahen_ZA
dc.contributor.authorFitzgerald, Graceen_ZA
dc.contributor.authorSeeley, Janeten_ZA
dc.contributor.authorSchatz, Eniden_ZA
dc.contributor.authorNachega, Jean B.en_ZA
dc.contributor.authorNegin, Joelen_ZA
dc.date.accessioned2021-11-17T13:10:55Z
dc.date.available2021-11-17T13:10:55Z
dc.date.issued2019
dc.descriptionCITATION: Soomro, N., et al. 2019. Comparison of antiretroviral therapy adherence among HIV-infected older adults with younger adults in Africa : systematic review and meta-analysis. AIDS and Behavior, 23:445-458, doi:10.1007/s10461-018-2196-0.
dc.descriptionhttps://link.springer.com/article/10.1007/s10461-018-2196-0
dc.description.abstractENGLISH ABSTRACT: As access to antiretroviral treatment in low- and middle-income countries improves, the number of older adults (aged ≥ 50 years) living with HIV is increasing. This study compares the adherence to antiretroviral treatment among older adults to that of younger adults living in Africa. We searched PubMed, Medline, Cochrane CENTRAL, CINAHL, Google Scholar and EMBASE for keywords (HIV, ART, compliance, adherence, age, Africa) on publications from 1st Jan 2000 to 1st March 2016. Eligible studies were pooled for meta-analysis using a random-effects model, with the odds ratio as the primary outcome. Twenty studies were included, among them were five randomised trials and five cohort studies. Overall, we pooled data for 148,819 individuals in two groups (older and younger adults) and found no significant difference in adherence between them [odds ratio (OR) 1.01; 95% CI 0.94–1.09]. Subgroup analyses of studies using medication possession ratio and clinician counts to measure adherence revealed higher proportions of older adults were adherent to medication regimens compared with younger adults (OR 1.06; 95% CI 1.02–1.11). Antiretroviral treatment adherence levels among older and younger adults in Africa are comparable. Further research is required to identify specific barriers to adherence in the aging HIV affected population in Africa which will help in development of interventions to improve their clinical outcomes and quality of life.en_ZA
dc.description.urihttps://link.springer.com
dc.description.versionPublisher's version
dc.format.extent14 pagesen_ZA
dc.identifier.citationSoomro, N., et al. 2019. Comparison of antiretroviral therapy adherence among HIV-infected older adults with younger adults in Africa : systematic review and meta-analysis. AIDS and Behavior, 23:445-458, doi:10.1007/s10461-018-2196-0
dc.identifier.issn1573-3254 (online)
dc.identifier.issn1090-7165 (print)
dc.identifier.otherdoi:10.1007/s10461-018-2196-0
dc.identifier.urihttp://hdl.handle.net/10019.1/123471
dc.language.isoen_ZAen_ZA
dc.publisherSpringeren_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectHIV-positive personsen_ZA
dc.subjectAntiretroviral agentsen_ZA
dc.subjectMeta-analysisen_ZA
dc.subjectSystematic reviews (Medical researchen_ZA
dc.titleComparison of antiretroviral therapy adherence among HIV-infected older adults with younger adults in Africa : systematic review and meta-analysisen_ZA
dc.typeArticleen_ZA
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