Serotonergic agents in the treatment of hypothalamic obesity syndrome: A case report

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dc.contributor.authorJordaan G.P.
dc.contributor.authorRoberts M.C.
dc.contributor.authorEmsley R.A.
dc.date.accessioned2011-05-15T16:16:40Z
dc.date.available2011-05-15T16:16:40Z
dc.date.issued1996
dc.description.abstractThe hypothalamic obesity syndrome is characterized by hyperphagia and excessive weight gain in the presence of demonstrable hypothalamic injury. There have been no previous reports describing the use of serotonergic agents in this condition. We report on a patient with severe hyperphagia and obesity secondary to a hypothalamic lesion, who was treated with consecutive courses of fluoxetine and fenfluramine. Neither treatment resulted in a reduction in food intake or weight. Treatment of hypothalamic obesity with serotonergic agents appears to be of little value, probably because they exert their effect via intact serotonergic-sensitive hypothalamic nuclei.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Eating Disorders
dc.identifier.citation20
dc.identifier.citation1
dc.identifier.issn02763478
dc.identifier.other10.1002/(SICI)1098-108X(199607)20:1<111::AID-EAT13>3.0.CO;2-7
dc.identifier.urihttp://hdl.handle.net/10019.1/13881
dc.subjectfenfluramine
dc.subjectfluoxetine
dc.subjectadult
dc.subjectarticle
dc.subjectbody weight
dc.subjectcase report
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjecthuman
dc.subjecthypothalamus
dc.subjecthypothalamus disease
dc.subjectmale
dc.subjectobesity
dc.subjectpriority journal
dc.subjectAdult
dc.subjectBody Weight
dc.subjectBrain Damage, Chronic
dc.subjectDose-Response Relationship, Drug
dc.subjectFenfluramine
dc.subjectFluoxetine
dc.subjectHumans
dc.subjectHyperphagia
dc.subjectHypothalamic Diseases
dc.subjectMale
dc.subjectObesity
dc.subjectSerotonin Uptake Inhibitors
dc.subjectTreatment Failure
dc.titleSerotonergic agents in the treatment of hypothalamic obesity syndrome: A case report
dc.typeArticle
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