Fetal general movements and brain sonography in a population at risk for preterm birth

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dc.contributor.authorRosier-van Dunne F.M.F.
dc.contributor.authorvan Wezel-Meijler G.
dc.contributor.authorBakker M.P.S.
dc.contributor.authorOdendaal H.J.
dc.contributor.authorde Vries J.I.P.
dc.date.accessioned2011-05-15T16:16:16Z
dc.date.available2011-05-15T16:16:16Z
dc.date.issued2010
dc.description.abstractBackground: General movements (GMs) assessed three months post term are related to brain injury and neurological outcome. Aims: To study GMs in fetuses and their predictive value for echogenicity changes in the fetal brain. Study design: Prospective study of fetal GMs (classified as normal or abnormal) and echogenicity changes in the periventricular, basal ganglia/thalami area, and ventricular system (classified as absent, mild or moderate). Subjects: 121 fetuses from pregnancies affected by hypertensive disorders and/or preterm labour, at risk for preterm birth (26-34 weeks gestational age). Outcome measures: Prevalence of abnormal GMs, GM parameters (amplitude, speed and complexity), and moderate echogenicity changes in the fetal brain (periventricular ≥ IB, intraventricular grade II/III, and basal ganglia/thalamus locally increased). Predictive values of GMs for clinical parameters and moderate echogenicity changes. Results: GMs were abnormal in 58%, with amplitude affected in 96%, and speed and complexity in 59%. Abnormal GMs correlated with oligohydramnios (p = 0.002) and hypertensive disorders (p = 0.015). Echogenicity changes of the brain were absent, mild and moderate in 27%, 39% and 31%, respectively. The sensitivity of GMs for moderate echogenicity changes in the three areas combined was 0.65, and the periventricular area 0.85, specificity both 0.44, negative predictive values 0.73 and 0.96 respectively. Conclusions: Qualitative abnormal GMs are frequent in fetuses of compromised pregnancies, and correlate with hypertensive disorders and oligohydramnios. The amplitude of GMs was most frequently affected. Abnormal GMs relate to moderate echogenicity changes especially in the periventricular area of the fetal brain, while normal GMs predict absence of moderate echogenicity changes. © 2010 Elsevier Ltd. All rights reserved.
dc.description.versionArticle
dc.identifier.citationEarly Human Development
dc.identifier.citation86
dc.identifier.citation2
dc.identifier.issn03783782
dc.identifier.other10.1016/j.earlhumdev.2010.01.026
dc.identifier.urihttp://hdl.handle.net/10019.1/13705
dc.subjectarticle
dc.subjectbasal ganglion
dc.subjectbrain radiography
dc.subjectbrain ventricle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease severity
dc.subjectechography
dc.subjectfemale
dc.subjectfetus
dc.subjectfetus movement
dc.subjectgestational age
dc.subjecthuman
dc.subjecthypertension
dc.subjectoligohydramnios
dc.subjectpopulation risk
dc.subjectprematurity
dc.subjectprevalence
dc.subjectprospective study
dc.subjectrisk assessment
dc.subjectthalamus
dc.subjectAdult
dc.subjectBasal Ganglia
dc.subjectBrain
dc.subjectCerebral Ventricles
dc.subjectEchoencephalography
dc.subjectFemale
dc.subjectFetal Movement
dc.subjectGestational Age
dc.subjectHumans
dc.subjectOligohydramnios
dc.subjectPre-Eclampsia
dc.subjectPredictive Value of Tests
dc.subjectPregnancy
dc.subjectPremature Birth
dc.subjectProspective Studies
dc.subjectPsychomotor Disorders
dc.subjectUltrasonography, Prenatal
dc.titleFetal general movements and brain sonography in a population at risk for preterm birth
dc.typeArticle
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