Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients

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dc.contributor.authorWeiner, Januaryen_ZA
dc.contributor.authorParida, Shreemanta K.en_ZA
dc.contributor.authorMaertzdorf, Jeroenen_ZA
dc.contributor.authorBlack, Gillian F.en_ZA
dc.contributor.authorRepsilber, Dirken_ZA
dc.contributor.authorTelaar, Annaen_ZA
dc.contributor.authorMohney, Robert P.en_ZA
dc.contributor.authorArndt-Sullivan, Cordeliaen_ZA
dc.contributor.authorGanoza, Christian A.en_ZA
dc.contributor.authorFae, Kellen C.en_ZA
dc.contributor.authorWalzl, Gerharden_ZA
dc.contributor.authorKaufmann, Stefan H. E.en_ZA
dc.date.accessioned2012-08-17T12:36:50Z
dc.date.available2012-08-17T12:36:50Z
dc.date.issued2012-07-23
dc.descriptionCITATION: Weiner, J. et al. 2012. Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients. PLoS ONE, 7(7): e40221, doi:10.1371/journal.pone.0040221.
dc.descriptionThe original publication is available at http://journals.plos.org/plosone
dc.description.abstractAlthough tuberculosis (TB) causes more deaths than any other pathogen, most infected individuals harbor the pathogen without signs of disease. We explored the metabolome of >400 small molecules in serum of uninfected individuals, latently infected healthy individuals and patients with active TB. We identified changes in amino acid, lipid and nucleotide metabolism pathways, providing evidence for anti-inflammatory metabolomic changes in TB. Metabolic profiles indicate increased activity of indoleamine 2,3 dioxygenase 1 (IDO1), decreased phospholipase activity, increased abundance of adenosine metabolism products, as well as indicators of fibrotic lesions in active disease as compared to latent infection. Consistent with our predictions, we experimentally demonstrate TB-induced IDO1 activity. Furthermore, we demonstrate a link between metabolic profiles and cytokine signaling. Finally, we show that 20 metabolites are sufficient for robust discrimination of TB patients from healthy individuals. Our results provide specific insights into the biology of TB and pave the way for the rational development of metabolic biomarkers for TB. © 2012 Weiner et al.
dc.description.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040221
dc.description.versionPublisher's version
dc.format.extent14 pages
dc.identifier.citationWeiner, J. et al. 2012. Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients. PLoS ONE, 7(7): e40221, doi:10.1371/journal.pone.0040221.
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0040221
dc.identifier.urihttp://hdl.handle.net/10019.1/49279
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights.holderAuthors retain copyright
dc.subjectTuberculosisen_ZA
dc.titleBiomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patientsen_ZA
dc.typeArticle
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