Feasibility of a large cohort study in sub-Saharan Africa assessed through a four-country study

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dc.contributor.authorDalal, Shonaen_ZA
dc.contributor.authorHolmes, Michelle D.en_ZA
dc.contributor.authorLaurence, Carienen_ZA
dc.contributor.authorBajunirwe, Francisen_ZA
dc.contributor.authorGuwatudde, Daviden_ZA
dc.contributor.authorNjelekela, Marinaen_ZA
dc.contributor.authorAdebamowo, Clementen_ZA
dc.contributor.authorNankya-Mutyoba, Joanen_ZA
dc.contributor.authorChiwanga, Faraja S.en_ZA
dc.contributor.authorVolmink, Jimmyen_ZA
dc.contributor.authorAjayi, Ikeoluwapoen_ZA
dc.contributor.authorKalyesubula, Roberten_ZA
dc.contributor.authorReid, Todd G.en_ZA
dc.contributor.authorDockery, Douglasen_ZA
dc.contributor.authorHemenway, Daviden_ZA
dc.contributor.authorAdami, Hans-Oloven_ZA
dc.date.accessioned2016-08-10T06:56:15Z
dc.date.available2016-08-10T06:56:15Z
dc.date.issued2015-05-25
dc.descriptionCITATION: Dalal, S. et al. 2015. Feasibility of a large cohort study in sub-Saharan Africa assessed through a four-country study. Global Health Action, 8:27422, doi:10.3402/gha.v8.27422.
dc.descriptionThe original publication is available at http://www.globalhealthaction.net
dc.description.abstractBackground: Large prospective epidemiologic studies are vital in determining disease etiology and forming national health policy. Yet, such studies do not exist in sub-Saharan Africa (SSA) notwithstanding the growing burden of chronic diseases. Objective: We explored the feasibility of establishing a large-scale multicountry prospective study at five sites in four sub-Saharan countries. Design: Based on country-specific considerations of feasibility, Nigeria enrolled health care professionals, South Africa and Tanzania enrolled teachers, and Uganda enrolled village residents at one rural and one periurban site each. All sites used a 6-month follow-up period but different approaches for data collection, namely standardized questionnaires filled out by participants or face-to-face interviews. Results: We enrolled 1415 participants from five sites (range 200489) with a median age of 41 years. Approximately half had access to clean-burning cooking fuel and 70% to piped drinking water, yet 92% had access to a mobile phone. The prevalence of chronic diseases was 49% among 45- to 54-year-olds and was dominated by hypertension (21.7% overall) ranging from 4.5 to 31.2% across sites and a serious injury in the past 12 months (12.4% overall). About 80% of participants indicated willingness to provide blood samples. At 6-month follow-up, 68% completed a questionnaire (45 to 96% across sites) with evidence that mobile phones were particularly useful. Conclusions: Our pilot study indicates that a large-scale prospective study in SSA is feasible, and the burden of chronic disease in SSA may already be substantial necessitating urgent etiologic research and primary prevention.en_ZA
dc.description.urihttp://www.globalhealthaction.net/index.php/gha/article/view/27422
dc.description.versionPublisher's version
dc.format.extent10 pages ; illustrations
dc.identifier.citationDalal, S. et al. 2015. Feasibility of a large cohort study in sub-Saharan Africa assessed through a four-country study. Global Health Action, 8:27422, doi:10.3402/gha.v8.27422.
dc.identifier.issn1654-9880 (online)
dc.identifier.otherdoi:10.3402/gha.v8.27422
dc.identifier.urihttp://hdl.handle.net/10019.1/99348
dc.language.isoen_ZAen_ZA
dc.publisherCo-Action Publishing
dc.rights.holderAuthors retain copyright
dc.subjectChronic diseases -- Epidemiology -- Africa, Sub-Saharanen_ZA
dc.subjectFeasibility studies -- Africa, Sub-Saharanen_ZA
dc.titleFeasibility of a large cohort study in sub-Saharan Africa assessed through a four-country studyen_ZA
dc.typeArticleen_ZA
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