Clinical perspectives on treatment of rifampicin-resistant/multidrug-resistant TB

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dc.contributor.authorCox, V.en_ZA
dc.contributor.authorMcKenna, L.en_ZA
dc.contributor.authorAcquah, R.en_ZA
dc.contributor.authorReuter, A.en_ZA
dc.contributor.authorWasserman, S.en_ZA
dc.contributor.authorVambe, D.en_ZA
dc.contributor.authorUstero, P.en_ZA
dc.contributor.authorUdwadia, Z.en_ZA
dc.contributor.authorTrivino-Duran, L.en_ZA
dc.contributor.authorTommasi, M.en_ZA
dc.contributor.authorSkrahina, A.en_ZA
dc.contributor.authorSeddon, J. A.en_ZA
dc.contributor.authorRodolfo, R.en_ZA
dc.contributor.authorRich, M.en_ZA
dc.contributor.authorPadanilam, X.en_ZA
dc.contributor.authorOyewusi, L.en_ZA
dc.contributor.authorOhler, L.en_ZA
dc.contributor.authorLungu, P.en_ZA
dc.contributor.authorLoveday, M.en_ZA
dc.contributor.authorKhan, U.en_ZA
dc.contributor.authorKhan, P.en_ZA
dc.contributor.authorHughes, J.en_ZA
dc.contributor.authorHewison, C.en_ZA
dc.contributor.authorGuglielmetti, L.en_ZA
dc.contributor.authorFurin, J.en_ZA
dc.date.accessioned2022-09-26T12:10:41Zen_ZA
dc.date.available2022-09-26T12:10:41Zen_ZA
dc.date.issued2020-11en_ZA
dc.descriptionCITATION: Cox, V. et al. 2020. Clinical perspectives on treatment of rifampicin-resistant/multidrug-resistant TB. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 24(11):1134–1144. doi:10.5588/ijtld.20.0330en_ZA
dc.descriptionThe original publication is available at https://www.ingentaconnect.com/content/iuatld/ijtlden_ZA
dc.description.abstractRapid diagnostics, newer drugs, repurposed medications, and shorter regimens have radically altered the landscape for treating rifampicin-resistant TB (RR-TB) and multidrug-resistant TB (MDR-TB). There are multiple ongoing clinical trials aiming to build a robust evidence base to guide RR/MDR-TB treatment, and both observational studies and programmatic data have contributed to advancing the treatment field. In December 2019, the WHO issued their second ‘Rapid Communication´ related to RR-TB management. This reiterated their prior recommendation that a majority of people with RR/MDR-TB receive all-oral treatment regimens, and now allow for specific shorter duration regimens to be used programmatically as well. Many TB programs need clinical advice as they seek to roll out such regimens in their specific setting. In this Perspective, we highlight our early experiences and lessons learned from working with National TB Programs, adult and pediatric clinicians and civil society, in optimizing treatment of RR/MDR-TB, using shorter, highly-effective, oral regimens for the majority of people with RR/MDR-TB.en_ZA
dc.description.urihttps://www.ingentaconnect.com/content/iuatld/ijtld/2020/00000024/00000011/art00002en_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extent12 pagesen_ZA
dc.identifier.citationCox, V. et al. 2020. Clinical perspectives on treatment of rifampicin-resistant/multidrug-resistant TB. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 24(11):1134–1144. doi:10.5588/ijtld.20.0330en_ZA
dc.identifier.issn1815-7920 (online)en_ZA
dc.identifier.issn1027-3719 (print)en_ZA
dc.identifier.otherdoi:10.5588/ijtld.20.0330en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125750en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherInternational Union Against Tuberculosis and Lung Diseaseen_ZA
dc.rights.holderThe Unionen_ZA
dc.subjectMultidrug-resistant tuberculosisen_ZA
dc.subjectDrug-resistanten_ZA
dc.subjectHuman rightsen_ZA
dc.subjectRifampin -- Treatmenten_ZA
dc.subjectDrug resistanceen_ZA
dc.subjectAnti-infective agentsen_ZA
dc.titleClinical perspectives on treatment of rifampicin-resistant/multidrug-resistant TBen_ZA
dc.typeArticleen_ZA
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