SNP/RD typing of Mycobacterium tuberculosis Beijing strains reveals local and worldwide disseminated clonal complexes

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dc.contributor.authorSchurch, Anita C.en_ZA
dc.contributor.authorKremer, Kristinen_ZA
dc.contributor.authorHendriks, Amber C. A.en_ZA
dc.contributor.authorFreyee, Benthe
dc.contributor.authorMcEvoy, Christopher R. E.en_ZA
dc.contributor.authorVan Crevel, Reinouten_ZA
dc.contributor.authorBoeree, Martin J.en_ZA
dc.contributor.authorVan Helden, Paulen_ZA
dc.contributor.authorWarren, Robin M.en_ZA
dc.contributor.authorSiezen, Roland J.en_ZA
dc.contributor.authorVan Soolingen, Dicken_ZA
dc.date.accessioned2012-01-18T08:06:38Z
dc.date.available2012-01-18T08:06:38Z
dc.date.issued2011-12-05
dc.descriptionCITATION: Schurch, A. C. et al. 2011. SNP/RD typing of Mycobacterium tuberculosis Beijing strains reveals local and worldwide disseminated clonal complexes. PLoS ONE, 6(12): e28365, doi:10.1371/journal.pone.0028365.
dc.descriptionThe original publication is available at http://journals.plos.org/plosone
dc.description.abstractThe Beijing strain is one of the most successful genotypes of Mycobacterium tuberculosis worldwide and appears to be highly homogenous according to existing genotyping methods. To type Beijing strains reliably we developed a robust typing scheme using single nucleotide polymorphisms (SNPs) and regions of difference (RDs) derived from whole-genome sequencing data of eight Beijing strains. SNP/RD typing of 259 M. tuberculosis isolates originating from 45 countries worldwide discriminated 27 clonal complexes within the Beijing genotype family. A total of 16 Beijing clonal complexes contained more than one isolate of known origin, of which two clonal complexes were strongly associated with South African origin. The remaining 14 clonal complexes encompassed isolates from different countries. Even highly resolved clonal complexes comprised isolates from distinct geographical sites. Our results suggest that Beijing strains spread globally on multiple occasions and that the tuberculosis epidemic caused by the Beijing genotype is at least partially driven by modern migration patterns. The SNPs and RDs presented in this study will facilitate future molecular epidemiological and phylogenetic studies on Beijing strains.
dc.description.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028365
dc.description.versionPublisher's version
dc.format.extent9 pages
dc.identifier.citationSchurch, A. C. et al. 2011. SNP/RD typing of Mycobacterium tuberculosis Beijing strains reveals local and worldwide disseminated clonal complexes. PLoS ONE, 6(12): e28365, doi:10.1371/journal.pone.0028365.
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0028365
dc.identifier.urihttp://hdl.handle.net/10019.1/19194
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights.holderAuthors retain copyright
dc.subjectTuberculosisen_ZA
dc.subjectBeijing strainsen_ZA
dc.titleSNP/RD typing of Mycobacterium tuberculosis Beijing strains reveals local and worldwide disseminated clonal complexesen_ZA
dc.typeArticle
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