Isolation of a new human herpesvirus producing a lytic infection of helper (CD4) T-lymphocytes in peripheral blood lymphocyte cultures. Another cause of acquired immunodeficiency

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dc.contributor.authorBecker, W. B.en_ZA
dc.contributor.authorEngelbrecht, S.en_ZA
dc.contributor.authorBecker, M. L. B.en_ZA
dc.contributor.authorPiek, C.en_ZA
dc.contributor.authorRobson, B. A.en_ZA
dc.contributor.authorWood, L.en_ZA
dc.contributor.authorJacobs, P.en_ZA
dc.date.accessioned2011-03-18T14:59:36Z
dc.date.available2011-03-18T14:59:36Z
dc.date.issued1988-12
dc.descriptionCITATION: Becker W. B., et al. 1988. Isolation of a new human herpesvirus producing a lytic infection of helper (CD4) T-lymphocytes in peripheral blood lymphocyte cultures. Another cause of acquired immunodeficiency. A case report. S Afr Med J, 74:610-614.en_ZA
dc.descriptionThe original publication is available at http://www.samj.org.zaen_ZA
dc.description.abstractA new human helper (CD4) T-lymphotropic herpesvirus (HTLHV) was first isolated in February 1985 from the cultured peripheral blood lymphocytes (PBL) of a patient with the acquired immunodeficiency syndrome, and subsequently from the PBL of 1 patient with hairy cell leukaemia and 2 patients with lymphoproliferative disease associated with human T-lymphotropic virus type I infection. The viruses could be serially subcultured in umbilical cord PBL cultures in which they infected helper (CD4) T-lymphocytes producing multinucleate giant cells with intranuclear inclusions followed by cell lysis. Electron microscopy of infected cultures revealed that the isolates were herpesviruses. Specific DNA probing showed that the 4 isolates were related to one another but were distinct from cytomegalovirus, Epstein-Barr virus, Herpes-virus hominis types 1 and 2, and varicella-zoster virus. HTLHV lyses the same target cell as human immunodeficiency virus in PBL cultures suggesting that it may have a similar potential to cause acquired immune deficiency. The development of an unequivocally diagnostic serological test is a priority, so that the epidemiology and pathogenesis of HTLHV infection can be studied.en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.identifier.citationBecker W. B., et al. 1988. Isolation of a new human herpesvirus producing a lytic infection of helper (CD4) T-lymphocytes in peripheral blood lymphocyte cultures. Another cause of acquired immunodeficiency. A case report. S Afr Med J, 74:610-614.en_ZA
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7928
dc.language.isoen
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.rights.holderSouth African Medical Journalen_ZA
dc.subjectherpesvirusen_ZA
dc.subjectblood lymphocyteen_ZA
dc.subjectimmune deficiencyen_ZA
dc.titleIsolation of a new human herpesvirus producing a lytic infection of helper (CD4) T-lymphocytes in peripheral blood lymphocyte cultures. Another cause of acquired immunodeficiencyen_ZA
dc.typeArticleen_ZA
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