Inflammation and oxidative stress in an obese state and the protective effects of gallic acid

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dc.contributor.authorDludla, Phiwayinkosi V.en_ZA
dc.contributor.authorNkambule, Bongani B.en_ZA
dc.contributor.authorJack, Babalwaen_ZA
dc.contributor.authorMkandla, Zibusisoen_ZA
dc.contributor.authorMutize, Tinasheen_ZA
dc.contributor.authorSilvestri, Soniaen_ZA
dc.contributor.authorOrlando, Patricken_ZA
dc.contributor.authorTiano, Lucaen_ZA
dc.contributor.authorLouw, Johanen_ZA
dc.contributor.authorMazibuko-Mbeje, Sithandiwe E.en_ZA
dc.date.accessioned2021-10-19T08:18:35Z
dc.date.available2021-10-19T08:18:35Z
dc.date.issued2019
dc.descriptionCITATION: Dludla, P. V. et al. 2019. Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid. Nutrients, 11(1). doi:10.3390/nu11010023.
dc.descriptionThe original publication is available at https://www.mdpi.com/journal/nutrients
dc.description.abstractENGLISH ABSTRACT: Metabolic complications in an obese state can be aggravated by an abnormal inflammatory response and enhanced production of reactive oxygen species. Pro-inflammatory response is known to be associated with the formation of toxic reactive oxygen species and subsequent generation of oxidative stress. Indeed, adipocytes from obese individuals display an altered adipokine profile, with upregulated expression and secretion of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin (IL-6). Interestingly, natural compounds, including phenolic enriched foods are increasingly explored for their ameliorative effects against various metabolic diseases. Of interest is gallic acid, a trihydroxybenzoic acid that has progressively demonstrated robust anti-obesity capabilities in various experimental models. In addition to reducing excessive lipid storage in obese subjects, gallic acid has been shown to specifically target the adipose tissue to suppress lipogenesis, improve insulin signaling, and concomitantly combat raised pro-inflammatory response and oxidative stress. This review will revise mechanisms involved in the pathophysiological effects of inflammation and oxidative stress in an obese state. To better inform on its therapeutic potential and improvement of human health, available evidence reporting on the anti-obesity properties of gallic acid and its derivatives will be discussed, with emphases on its modulatory effect on molecular mechanisms involved in insulin signaling, inflammation and oxidative stress.en_ZA
dc.description.urihttps://www.mdpi.com/2072-6643/11/1/23
dc.description.versionPublisher’s version
dc.format.extent29 pagesen_ZA
dc.identifier.citationDludla, P. V. et al. 2019. Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid. Nutrients, 11(1). doi:10.3390/nu11010023.
dc.identifier.issn2072-6643 (online)
dc.identifier.urihttp://hdl.handle.net/10019.1/123249
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthors retain rightsen_ZA
dc.subjectObesityen_ZA
dc.subjectInsulin resistanceen_ZA
dc.subjectInflammationen_ZA
dc.subjectOxidative stressen_ZA
dc.subjectGallic aciden_ZA
dc.subjectTherapeutic targeten_ZA
dc.titleInflammation and oxidative stress in an obese state and the protective effects of gallic aciden_ZA
dc.typeArticleen_ZA
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