The outcome of infants younger than 6 months requiring ventilation for pneumonia caused by Mycobacterium tuberculosis

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dc.contributor.authorGoussard P.
dc.contributor.authorGie R.P.
dc.contributor.authorKling S.
dc.contributor.authorSchaaf H.S.
dc.contributor.authorKritzinger F.
dc.contributor.authorAndronikou S.
dc.contributor.authorBeyers N.
dc.contributor.authorRossouw G.J.
dc.date.accessioned2011-05-15T16:17:40Z
dc.date.available2011-05-15T16:17:40Z
dc.date.issued2008
dc.description.abstractIntroduction: The outcome of young infants (<6 months) being ventilated for respiratory failure caused by Mycobacterium tuberculosis (MTB) has not been recorded. Patients and Methods: A descriptive study of children <6 months admitted to the PICU from 1 February 1999 to 31 December 2005 with MTB causing respiratory failure. Results: Seventeen infants were ventilated for respiratory failure caused by MTB: ten had ventilatory respiratory failure and seven had hypoxic failure. An index case was found in 47%. All chest radiographs (CXRs) were highly suggestive of tuberculosis. MTB was cultured in 15 cases. In the other two cases MTB was confirmed by histopathology. The median duration of ventilation was 6 days (range: 1-35 days) with a median PaO2/FiO2 of 85 and ventilatory index of 58. Transthoracic glandular enucleation was required to facilitate extubation in six babies. All the infants survived. At 6-month follow-up 35% had a normal CXR and all were asymptomatic. One child had CXR changes suggestive of bronchiectasis but was asymptomatic. Conclusion: The outcome of infants <6 months ventilated for respiratory failure caused by MTB is very good if TB is recognized timeously and appropriate management started. The diagnosis of TB in these infants can be made with a high index of suspicion and careful evaluation of the CXR. © 2008 Wiley-Liss, Inc.
dc.description.versionArticle
dc.identifier.citationPediatric Pulmonology
dc.identifier.citation43
dc.identifier.citation5
dc.identifier.issn87556863
dc.identifier.other10.1002/ppul.20812
dc.identifier.urihttp://hdl.handle.net/10019.1/14316
dc.subjectethambutol
dc.subjectethionamide
dc.subjectisoniazid
dc.subjectprednisone
dc.subjectpyrazinamide
dc.subjectrifampicin
dc.subjectarticle
dc.subjectartificial ventilation
dc.subjectbronchiectasis
dc.subjectclinical article
dc.subjectdescriptive research
dc.subjectextubation
dc.subjectfemale
dc.subjectfollow up
dc.subjectforced expiratory volume
dc.subjecthistopathology
dc.subjecthospital admission
dc.subjecthuman
dc.subjecthypoxia
dc.subjectinfant
dc.subjectmale
dc.subjectMycobacterium tuberculosis
dc.subjectoxygen tension
dc.subjectpneumonia
dc.subjectpriority journal
dc.subjectrespiratory failure
dc.subjectsurvival
dc.subjectthorax radiography
dc.subjecttreatment outcome
dc.subjecttuberculosis
dc.subjectBronchiectasis
dc.subjectBronchoscopy
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectInfant
dc.subjectLength of Stay
dc.subjectLung
dc.subjectMale
dc.subjectMycobacterium tuberculosis
dc.subjectPneumonia
dc.subjectRespiration, Artificial
dc.subjectRespiratory Insufficiency
dc.subjectTomography, X-Ray Computed
dc.subjectTreatment Outcome
dc.subjectTuberculosis
dc.titleThe outcome of infants younger than 6 months requiring ventilation for pneumonia caused by Mycobacterium tuberculosis
dc.typeArticle
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