EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy

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dc.contributor.authorStaljanssens, Willekeen_ZA
dc.contributor.authorStrobbe, Gregoren_ZA
dc.contributor.authorVan Holen, Roelen_ZA
dc.contributor.authorKeereman, Vincenten_ZA
dc.contributor.authorGadeyne, Stefanieen_ZA
dc.contributor.authorCarrette, Evelienen_ZA
dc.contributor.authorMeurs, Alfreden_ZA
dc.contributor.authorPittau, Francescaen_ZA
dc.contributor.authorMomjian, Shahanen_ZA
dc.contributor.authorSeeck, Margittaen_ZA
dc.contributor.authorBoon, Paulen_ZA
dc.contributor.authorVandenberghe, Stefaanen_ZA
dc.contributor.authorVulliemoz, Sergeen_ZA
dc.contributor.authorVonck, Kristlen_ZA
dc.contributor.authorVan Mierlo, Pieteren_ZA
dc.date.accessioned2018-10-29T09:47:31Z
dc.date.available2018-10-29T09:47:31Z
dc.date.issued2017-09
dc.descriptionCITATION: Staljanssens, W., et al . 2017. EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy. NeuroImage: Clinical, 16:689-698, doi:10.1016/j.nicl.2017.09.011
dc.descriptionThe original publication is available at http://www.sciencedirect.com
dc.description.abstractENGLISH ABSTRACT: the presurgical evaluation of epilepsy as a reflection of the irritative zone. ESI of ictal scalp EEG to localize the seizure onset zone (SOZ) remains challenging. We investigated the value of an approach for ictal imaging using ESI and functional connectivity analysis (FC). Ictal scalp EEG from 111 seizures in 27 patients who had Engel class I outcome at least 1 year following resective surgery was analyzed. For every seizure, an artifact-free epoch close to the seizure onset was selected and ESI using LORETA was applied. In addition, the reconstructed sources underwent FC using the spectrum-weighted Adaptive Directed Transfer Function. This resulted in the estimation of the SOZ in two ways: (i) the source with maximal power after ESI, (ii) the source with the strongest outgoing connections after combined ESI and FC. Next, we calculated the distance between the estimated SOZ and the border of the resected zone (RZ) for both approaches and called this the localization error ((i) LEpow and (ii) LEconn respectively). By comparing LEpow and LEconn, we assessed the added value of FC. The source with maximal power after ESI was inside the RZ (LEpow =0 mm) in 31% of the seizures and estimated within 10 mm from the border of the RZ (LEpow ≤10 mm) in 42%. Using ESI and FC, these numbers increased to 72% for LEconn =0 mm and 94% for LEconn ≤10 mm. FC provided a significant added value to ESI alone (p < 0.001). ESI combined with subsequent FC is able to localize the SOZ in a non-invasive way with high accuracy. Therefore it could be a valuable tool in the presurgical evaluation of epilepsy.en_ZA
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S2213158217301912?via%3Dihub
dc.description.versionPublisher's version
dc.format.extent10 pages : illustrationsen_ZA
dc.identifier.citationStaljanssens, W., et al . 2017. EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy. NeuroImage: Clinical, 16:689-698, doi:10.1016/j.nicl.2017.09.011
dc.identifier.issn2213-1582 (online)
dc.identifier.otherdoi:10.1016/j.nicl.2017.09.011
dc.identifier.urihttp://hdl.handle.net/10019.1/104618
dc.language.isoen_ZAen_ZA
dc.publisherElsevieren_ZA
dc.rights.holderAuthors retain copyright
dc.subjectDrug resistant epilepsyen_ZA
dc.subjectElectroencephalographyen_ZA
dc.subjectBrain -- Diseases -- Diagnosisen_ZA
dc.subjectEpilepsy -- Patientsen_ZA
dc.subjectEpilepsy -- Treatmenten_ZA
dc.subjectDrug resistance -- Epilepticsen_ZA
dc.titleEEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsyen_ZA
dc.typeArticleen_ZA
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