Circulating acute phase reactive proteins as indicators of infection in poorly controlled diabetes mellitus

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dc.contributor.authorVan Eeden S.F.
dc.contributor.authorStrachan A.F.
dc.contributor.authorHough S.F.
dc.date.accessioned2011-05-15T16:16:14Z
dc.date.available2011-05-15T16:16:14Z
dc.date.issued1988
dc.description.abstractSerum levels of six acute phase proteins (APP) - C-reactive protein (CRP), serum amyloid A (SAA), α1-antitrypsin, haptoglobin and complement fractions C3 and C4 - were serially studied in 24 patients with poorly controlled diabetes mellitus, ten of whom had unequivocal evidence of an underlying infection. In diabetic patients without infection, no change in APP levels was noted suggesting that hyperglycaemia per se does not quantitatively influence the acute phase response. No correlation between the presence of infection, and fever, leukocytosis, a raised erythrocyte sedimentation rate, or serum levels of α1-antitrypsin, haptoglobin or complement was apparent in these patients. However, serum CRP and SAA were initially increased 10-100 times above normal in diabetic patients with an underlying infection (P < 0.01); during the following week circulating levels of CRP and SAA decreased steadily in response to the infection being brought under control. We conclude that serial measurement of CRP and/or SAA is a sensitive, albeit non-specific, parameter to detect and monitor the activity of infection in patients with diabetes.
dc.description.versionArticle
dc.identifier.citationDiabetes Research and Clinical Practice
dc.identifier.citation5
dc.identifier.citation2
dc.identifier.issn01688227
dc.identifier.urihttp://hdl.handle.net/10019.1/13693
dc.subjectacute phase protein
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdiabetes mellitus
dc.subjecterythrocyte sedimentation rate
dc.subjecterythrocytosis
dc.subjectfever
dc.subjecthuman
dc.subjecthuman experiment
dc.subjecthyperglycemia
dc.subjectinfection
dc.subjectleukocytosis
dc.subjectpriority journal
dc.subjectsubcutaneous drug administration
dc.subjectAcute-Phase Proteins
dc.subjectAdolescent
dc.subjectAdult
dc.subjectBlood Glucose
dc.subjectCommunicable Diseases
dc.subjectDiabetes Mellitus, Insulin-Dependent
dc.subjectDiabetes Mellitus, Non-Insulin-Dependent
dc.subjectFemale
dc.subjectHemoglobin A, Glycosylated
dc.subjectHuman
dc.subjectLaboratory Techniques and Procedures
dc.subjectMale
dc.subjectSupport, Non-U.S. Gov't
dc.titleCirculating acute phase reactive proteins as indicators of infection in poorly controlled diabetes mellitus
dc.typeArticle
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