Delivery of antibiotics from cementless titanium-alloy cubes may be a novel way to control postoperative infections

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dc.contributor.authorOosthuizen, Gert A.en_ZA
dc.contributor.authorBezuidenhout, Martin B.en_ZA
dc.contributor.authorVan Staden, Anton D.en_ZA
dc.contributor.authorDimitrov, Dimitar M.en_ZA
dc.contributor.authorDicks, Leon Milner Theodore, 1961-en_ZA
dc.contributor.otherIndustrial Engineeringen_ZA
dc.contributor.otherMicrobiologyen_ZA
dc.date.accessioned2016-04-11T07:31:44Z
dc.date.available2016-04-11T07:31:44Z
dc.date.issued2015-02
dc.descriptionCITATION: Bezuidenhout, Martin. B., et al. 2015. Delivery of antibiotics from cementless Titanium-Alloy cubes may be a novel way to control postoperative infections. BioMed Research International, 2015(2015), ID 856859, doi.org/10.1155/2015/856859.
dc.descriptionThe original publication is available at http://www.hindawi.com/journals/bmri/en_ZA
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.
dc.description.abstractBacterial colonisation and biofilm formation onto orthopaedic devices are difficult to eradicate. In most cases infection is treated by surgical removal of the implant and cleaning of the infected area, followed by extensive treatment with broad-spectrum antibiotics. Such treatment causes great discomfort, is expensive, and is not always successful. In this study we report on the release of vancomycin through polyethersulfone membranes from channels in cementless titanium-alloy cubes. The cubes were constructed with LaserCUSING from Ti6Al4V ELI powder. Vancomycin was released by non-Fickian anomalous (constraint) diffusion. Approximately 50% of the vancomycin was released within the first 17 h. However, sustained delivery of vancomycin for 100 h was possible by reinjecting the channels. Refillable implants may be a novel way to control postoperative infections.en_ZA
dc.description.urihttp://www.hindawi.com/journals/bmri/2015/856859/en_ZA
dc.description.versionBacterial colonisation and biofilm formation onto orthopaedic devices are difficult to eradicate. In most cases infection is treated by surgical removal of the implant and cleaning of the infected area, followed by extensive treatment with broad-spectrum antibiotics. Such treatment causes great discomfort, is expensive, and is not always successful. In this study we report on the release of vancomycin through polyethersulfone membranes from channels in cementless titanium-alloy cubes. The cubes were constructed with LaserCUSING from Ti6Al4V ELI powder. Vancomycin was released by non-Fickian anomalous (constraint) diffusion. Approximately 50% of the vancomycin was released within the first 17 h. However, sustained delivery of vancomycin for 100 h was possible by reinjecting the channels. Refillable implants may be a novel way to control postoperative infections.en_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent7 pagesen_ZA
dc.identifier.citationBezuidenhout, Martin. B., et al. 2015. Delivery of antibiotics from cementless Titanium-Alloy cubes may be a novel way to control postoperative infections. BioMed Research International, 2015(2015), ID 856859, doi.org/10.1155/2015/856859.en_ZA
dc.identifier.otherDoi: 10.1155/2015/856859
dc.identifier.urihttp://hdl.handle.net/10019.1/98921
dc.language.isoen_ZAen_ZA
dc.publisherHindawi Publishing Corporationen_ZA
dc.rights.holderHindawi Publishing Corporationen_ZA
dc.subjectTitanium-Alloy cubesen_ZA
dc.subjectPostoperative infectionsen_ZA
dc.subjectBiofilm formationen_ZA
dc.subjectOrthopaedic devicesen_ZA
dc.subjectAntibiotics -- Biotechnologyen_ZA
dc.subjectInfection -- Treatmenten_ZA
dc.subjectVancomycin -- Diffusionen_ZA
dc.titleDelivery of antibiotics from cementless titanium-alloy cubes may be a novel way to control postoperative infectionsen_ZA
dc.typeArticleen_ZA
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