Rate of viral load change and adherence of HIV adult patients treated with Efavirenz or Nevirapine antiretroviral regimens at 24 and 48 weeks in Yaounde, Cameroon : a longitudinal cohort study

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dc.contributor.authorChendi, Bih Hycentaen_ZA
dc.contributor.authorAssoumou, Marie Claire Okomoen_ZA
dc.contributor.authorJacobs, Graeme Brendonen_ZA
dc.contributor.authorYekwa, Elsie Labanen_ZA
dc.contributor.authorLyonga, Emiliaen_ZA
dc.contributor.authorMesembe, Marthaen_ZA
dc.contributor.authorEyoh, Agnesen_ZA
dc.contributor.authorIkomey, George Mondindeen_ZA
dc.date.accessioned2021-07-29T10:17:38Z
dc.date.available2021-07-29T10:17:38Z
dc.date.issued2019
dc.descriptionCITATION: Chendi, B. H., et al. 2019. Rate of viral load change and adherence of HIV adult patients treated with Efavirenz or Nevirapine antiretroviral regimens at 24 and 48 weeks in Yaounde, Cameroon : a longitudinal cohort study. BMC Infectious Diseases, 19:194, doi:10.1186/s12879-019-3824-7.
dc.descriptionThe original publication is available at https://bmcinfectdis.biomedcentral.com
dc.description.abstractBackground: HIV-load decrease and suppression over time is associated with consistent adherence to antiretroviral therapy (ART). Our study aimed to evaluate the difference in viral load and adherence of patients treated with a combination of either Tenofovir (TDF), Lamivudine (3TC) and Efavirenz (EFV) or TDF / Zidovudine (AZT), 3TC and Nevirapine (NVP) regimens at 24 and 48 weeks. Methods: A longitudinal study was conducted from May 2016 to June 2017 among 256 HIV infected adult patients who were enrolled at two approved treatment hospitals in Yaoundé, before the start of first-line ART. Whole blood samples were collected using standard operating procedures. HIV-loads were determined by a quantitative RealTime PCR assay. Adherence was evaluated by pharmacy refill data records. Statistical analyses were performed using the PRISM 5.0 software. Results: Off the 256 HIV infected patients enrolled, 180 (70%) patients completed the study and 76 (30%) patients were lost to follow-up. The success rate in achieving viral load < 40 copies/ml was 1.8 times higher with the EFV regimen at 24 weeks and was 1.2 times higher in the NVP regimen at 48 weeks. At 48 weeks the treatment failure rate was 12.0 and 40.0% in patients on EFV and the NVP regimen, respectively. The rate of adherence varied in both ART based regimens with 84.0 to 74.0% for EFV and 65.5 to 62.5% for NVP, at 24 and 48 weeks respectively. Conclusion: In our study and setting, the rate of viral load decrease was higher in the NVP based regimen than with the EFV regimen. The adherence rate to ART was higher in the EFV regimen, compared to the NVP regimen. This adds to evidence that the EFV regimen is the preferred ART combination for non-nucleoside reverse transcriptase inhibitors (NNRTIs).en_ZA
dc.description.urihttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-3824-7
dc.description.versionPublisher's version
dc.format.extent8 pagesen_ZA
dc.identifier.citationChendi, B. H., et al. 2019. Rate of viral load change and adherence of HIV adult patients treated with Efavirenz or Nevirapine antiretroviral regimens at 24 and 48 weeks in Yaounde, Cameroon : a longitudinal cohort study. BMC Infectious Diseases, 19:194, doi:10.1186/s12879-019-3824-7
dc.identifier.issn1471-2334 (online)
dc.identifier.otherdoi:10.1186/s12879-019-3824-7
dc.identifier.urihttp://hdl.handle.net/10019.1/110787
dc.language.isoen_ZAen_ZA
dc.publisherBMC (part of Springer Nature)en_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectHIV infected adulten_ZA
dc.subjectCell adhesionen_ZA
dc.subjectNevirapineen_ZA
dc.subjectEfavirenzen_ZA
dc.subjectHIV-infected personsen_ZA
dc.titleRate of viral load change and adherence of HIV adult patients treated with Efavirenz or Nevirapine antiretroviral regimens at 24 and 48 weeks in Yaounde, Cameroon : a longitudinal cohort studyen_ZA
dc.typeArticleen_ZA
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