Stepwise regression analysis to study male and female factors impacting on pregnancy rate in an intrauterine insemination programme

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dc.contributor.authorMontanaro Gauci M.
dc.contributor.authorKruger T.F.
dc.contributor.authorCoetzee K.
dc.contributor.authorSmith K.
dc.contributor.authorVan Der Merwe J.P.
dc.contributor.authorLombard C.J.
dc.date.accessioned2011-05-15T16:15:25Z
dc.date.available2011-05-15T16:15:25Z
dc.date.issued2001
dc.description.abstractThe aim of this study was to evaluate the impact of male and female factors on the pregnancy rate in an intrauterine insemination (IUI) programme. Data on 522 cycles were retrospectively studied. All patients 39 years or younger were included in the study where data were available on male and female diagnosis, as well as on ovulation induction methodology. Regression analysis was possible on 495 cycles to study different factors affecting the pregnancy rate per treatment cycle. Logistic regression identified variables which were related to outcome and were subsequently incorporated into a statistical model. The number of follicles was found to have a linear association with the risk ratio (chance) of pregnancy. The age of the woman was also found to have a linear (negative) association with pregnancy. The percentage motility and percentage normal morphology (by strict criteria) of spermatozoa in the fresh ejaculate were the male factors that significantly and independently predicted the outcome. Percentage motility ≥ 50 was associated with a risk ratio of pregnancy of 2.95 compared to percentage motility < 50. Percentage normal sperm morphology > 14% was associated with a risk ratio of pregnancy of 1.8 compared to percentage normal morphology ≤ 14%. Female patients with idiopathic infertility were divided into three groups according to normal sperm morphology. The pregnancy rate per cycle was 2.63% (1/38) for the P (poor) pattern group (0-4% normal forms), 11.4% (17/149) for the G (good) pattern group (5-14%), and 24% (18/75) for the N (normal) pattern group (> 14% normal forms). A female diagnosis of endometriosis or tubal factor impacted negatively on the probability of pregnancy (risk ratio of 0.17), compared with other female diagnoses. Male and female factors contribute to pregnancy outcome, but the clinician can influence prognosis by increasing the number of follicles, especially in severe male factor cases.
dc.description.versionArticle
dc.identifier.citationAndrologia
dc.identifier.citation33
dc.identifier.citation3
dc.identifier.issn03034569
dc.identifier.urihttp://hdl.handle.net/10019.1/13333
dc.subjectadult
dc.subjectarticle
dc.subjectartificial insemination
dc.subjectcongenital malformation
dc.subjectendometriosis
dc.subjectfemale
dc.subjectfemale infertility
dc.subjecthuman
dc.subjectmale
dc.subjectmale infertility
dc.subjectmaternal age
dc.subjectpregnancy
dc.subjectregression analysis
dc.subjectretrospective study
dc.subjectspermatozoon
dc.subjectspermatozoon count
dc.subjectspermatozoon motility
dc.subjectstatistical model
dc.subjectuterine tube disease
dc.subjectAdult
dc.subjectEndometriosis
dc.subjectFallopian Tube Diseases
dc.subjectFemale
dc.subjectHumans
dc.subjectInfertility, Female
dc.subjectInfertility, Male
dc.subjectInsemination, Artificial
dc.subjectLogistic Models
dc.subjectMale
dc.subjectMaternal Age
dc.subjectPregnancy
dc.subjectRegression Analysis
dc.subjectRetrospective Studies
dc.subjectSperm Count
dc.subjectSperm Motility
dc.subjectSpermatozoa
dc.titleStepwise regression analysis to study male and female factors impacting on pregnancy rate in an intrauterine insemination programme
dc.typeArticle
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