Case report : an index of suspicion in hyponatraemia

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dc.contributor.authorBarkhuizen, Mariznaen_ZA
dc.contributor.authorHoffmann, Marizaen_ZA
dc.contributor.authorZöllner, Ekkehard W. A.en_ZA
dc.contributor.authorErasmus, Rajiv T.en_ZA
dc.contributor.authorZemlin, Annalise E.en_ZA
dc.date.accessioned2021-11-18T09:44:35Zen_ZA
dc.date.available2021-11-18T09:44:35Zen_ZA
dc.date.issued2019en_ZA
dc.descriptionCITATION: Barkhuizen, M., et al. 2019. Case report : an index of suspicion in hyponatraemia. Biochemia Medica, 29(1):011002, doi:10.11613/BM.2019.011002.en_ZA
dc.descriptionThe original publication is available at https://www.biochemia-medica.comen_ZA
dc.description.abstractSerum indices can give valuable information and should be interpreted as a result. Lipaemia can influence results through different mechanisms, an important one being the electrolyte exclusion effect. A case of pseudohyponatraemia due to this is reported. A 15-year-old female with type 2 diabetes was seen for follow-up. Her biochemistry results revealed severe hyponatraemia of 118 mmol/L. Her capillary glucose concentration was 13.7 mmol/L with a corrected sodium of 122 mmol/L. A lipaemic index of 3+ (absolute value 1320) was noted, which was not flagged by the laboratory information system, as it was below the critical lipaemia limit for sodium determination. Repeated analysis of the same sample using a direct ion selective electrode method, the serum sodium concentration was 134 mmol/L (sodium corrected for glucose = 138 mmol/L). A triglyceride concentration was requested, which was severely raised (100.1 mmol/L). The electrolyte exclusion effect is an analytical phenomenon that causes falsely low electrolyte concentrations in the presence of severe lipaemia or hyperproteinaemia when using indirect analytical methods. These methods are used on many modern-day automated chemistry analysers and should be considered in a patient with asymptomatic hyponatraemia.en_ZA
dc.description.urihttps://www.biochemia-medica.com/en/journal/29/1/10.11613/BM.2019.011002en_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent7 pagesen_ZA
dc.identifier.citationBarkhuizen, M., et al. 2019. Case report : an index of suspicion in hyponatraemia. Biochemia Medica, 29(1):011002, doi:10.11613/BM.2019.011002en_ZA
dc.identifier.issn1846-7482 (online)en_ZA
dc.identifier.issn1330-0962 (print)en_ZA
dc.identifier.otherdoi:10.11613/BM.2019.011002en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/123476en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherHrvatsko društvo za medicinsku biokemijuen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectPseudohyponatraemiaen_ZA
dc.subjectHyponatraemiaen_ZA
dc.subjectElectrolytesen_ZA
dc.subjectSerum indicesen_ZA
dc.titleCase report : an index of suspicion in hyponatraemiaen_ZA
dc.typeArticleen_ZA
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