Multi-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohort

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dc.contributor.authorMüller, Stephanie J.en_ZA
dc.contributor.authorHaiko, Schurzen_Za
dc.contributor.authorTromp, Gerarden_ZA
dc.contributor.authorVan der Spuy, Gian D.en_ZA
dc.contributor.authorHoal, Eileen G.en_ZA
dc.contributor.authorVan Helden, Paul D.en_ZA
dc.contributor.authorOwusu-Dabo, Ellisen_ZA
dc.contributor.authorMeyer, Christian G.en_ZA
dc.contributor.authorMuntau, Birgiten_ZA
dc.contributor.authorThye, Thorstenen_ZA
dc.contributor.authorNiemann, Stefanen_ZA
dc.contributor.authorWarren, Robin M.en_ZA
dc.contributor.authorStreicher, Elizabethen_ZA
dc.contributor.authorMuller, Marloen_ZA
dc.contributor.authorKinnear, Craigen_ZA
dc.date.accessioned2023-04-18T13:02:01Zen_ZA
dc.date.available2023-04-18T13:02:01Zen_ZA
dc.date.issued2021-04en_ZA
dc.descriptionCITATION: Müller, S. J. et al. 2021. A multi-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohort. Genomics 113 (2021) 1802–1815. doi.10.1016/j.ygeno.2021.04.024en_ZA
dc.descriptionThe original publication is available at: sciencedirect.comen_ZA
dc.description.abstractDespite decades of research and advancements in diagnostics and treatment, tuberculosis remains a major public health concern. New computational methods are needed to interrogate the intersection of host- and bacterial genomes. Paired host genotype datum and infecting bacterial isolate information were analysed for associations using a multinomial logistic regression framework implemented in SNPTest. A cohort of 853 admixed South African participants and a Ghanaian cohort of 1359 participants were included. Two directly genotyped variants, namely rs529920 and rs41472447, were identified in the Ghanaian cohort as being statistically significantly associated with risk for infection with strains of different members of the MTBC. Thus, a multinomial logistic regression using paired host-pathogen data may prove valuable for investigating the complex relationships driving infectious disease.en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extent14 pagesen_ZA
dc.identifier.citationMüller, S. J. et al. 2021. A multi-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohort. Genomics 113 (2021) 1802–1815. doi.10.1016/j.ygeno.2021.04.024en_ZA
dc.identifier.issn0888-7543 (online)en_ZA
dc.identifier.otherdoi.10.1016/j.ygeno.2021.04.024en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126796en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherElsevier Inc.en_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectMycobacterium tuberculosisen_ZA
dc.subjectTuberculosis -- Pathogenesisen_ZA
dc.subjectBacterial genomesen_ZA
dc.titleMulti-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohorten_ZA
dc.typeArticleen_ZA
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