An overview of analgesics : NSAIDs, paracetamol, and topical analgesics Part 1

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dc.contributor.authorVan Rensburg, R.en_ZA
dc.contributor.authorReuter, H.en_ZA
dc.date.accessioned2021-09-01T08:48:08Z
dc.date.available2021-09-01T08:48:08Z
dc.date.issued2019
dc.descriptionCITATION: Van Rensburg, R. & Reuter, H. 2019. An overview of analgesics : NSAIDs, paracetamol, and topical analgesics Part 1. South African Family Practice, 61(1):S4-S10, doi:10.1080/20786190.2019.1610228.
dc.descriptionThe original publication is available at https://www.tandfonline.com
dc.description.abstractENGLISH ABSTRACT: Pain is a complex and unique experience. It encompasses several pathways, involving nociceptive signal generation (transduction) and propagation (transmission), as well as perception and modulation of the nociceptive stimuli. Nonsteroidal anti-inflammatory drugs (NSAIDs) primarily exert their analgesic effects through inhibition of cyclooxygenase (COX) enzymes, thereby attenuating prostaglandin synthesis. The COX-2 selective NSAIDs (coxibs) and aspirin have also been shown to reduce colorectal cancers, presumably by prostaglandin-inhibition mechanisms. Paracetamol appears to have both peripheral and central effects. The postulated mechanism for its peripheral effects is indirect COX inhibition, while the central effects are thought to be mediated by modulation of descending pain inhibition pathways. Topical analgesics are available in various formulations. The topical NSAIDs have the same mechanism of action as the systemic formulations, but with less systemic absorption and effects. The local anaesthetics provide a dense sensory block via inhibition of nerve impulse transmission, and are available in percutaneous and transdermal preparations. Capsicum is effective for neuropathic pain, and acts by stimulating and then desensitising peripheral sensory nerves.en_ZA
dc.description.urihttps://www.tandfonline.com/doi/full/10.1080/20786190.2019.1610228
dc.description.versionPublisher's version
dc.format.extent8 pagesen_ZA
dc.identifier.citationVan Rensburg, R. & Reuter, H. 2019. An overview of analgesics : NSAIDs, paracetamol, and topical analgesics Part 1. South African Family Practice, 61(1):S4-S10, doi:10.1080/20786190.2019.1610228
dc.identifier.issn2078-6204 (online)
dc.identifier.issn2078-6190 (print)
dc.identifier.otherdoi:10.1080/20786190.2019.1610228
dc.identifier.urihttp://hdl.handle.net/10019.1/122977
dc.language.isoen_ZAen_ZA
dc.publisherTaylor and Francisen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectNociceptionen_ZA
dc.subjectAnalgesicsen_ZA
dc.subjectPain-killing drugsen_ZA
dc.subjectParacetamolen_ZA
dc.subjectAnalgesiaen_ZA
dc.titleAn overview of analgesics : NSAIDs, paracetamol, and topical analgesics Part 1en_ZA
dc.typeArticleen_ZA
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