A role for mitochondrial DNA in the pathogenesis of radiation-induced myelodysplasia and secondary leukemia

Simple item page
dc.contributor.authorHatfill S.J.
dc.contributor.authorLa Cock C.J.R.
dc.contributor.authorLaubscher R.
dc.contributor.authorDowning T.G.
dc.contributor.authorKirby R.
dc.date.accessioned2011-05-15T16:17:19Z
dc.date.available2011-05-15T16:17:19Z
dc.date.issued1993
dc.description.abstractThe onset of acute myeloid leukemia following ionizing radiation or alkylating agent exposure is antedated months to years by the development of 'preleukemia', or secondary myelodysplastic syndrome (sMDS). Mitochondrial abnormalities induced by chloramphenicol and clonal deletions of mitochondrial DNA (mt DNA) in the bone marrow create hematological defects similar to sMDS, and abnormal dimers of mt DNA are observed in acute leukemia. This suggests a role for mt DNA in the pathogenesis of sMDS and secondary leukemia. We outline disparate experimental evidence to support this concept and suggest a role for select protease inhibitors in the clinical management of this disorder.
dc.description.versionReview
dc.identifier.citationLeukemia Research
dc.identifier.citation17
dc.identifier.citation11
dc.identifier.issn01452126
dc.identifier.other10.1016/0145-2126(93)90036-K
dc.identifier.urihttp://hdl.handle.net/10019.1/14164
dc.subjectalkylating agent
dc.subjectantipain
dc.subjectchloramphenicol
dc.subjectleupeptin
dc.subjectmitochondrial dna
dc.subjectproteinase inhibitor
dc.subjectadult
dc.subjectbone marrow
dc.subjectdimerization
dc.subjectgene deletion
dc.subjecthuman
dc.subjectlymphocyte transformation
dc.subjectmale
dc.subjectmyelodysplasia
dc.subjectmyelodysplastic syndrome
dc.subjectpreleukemia
dc.subjectpriority journal
dc.subjectradiation carcinogenesis
dc.subjectreview
dc.subjectBone Marrow
dc.subjectDNA, Mitochondrial
dc.subjectHuman
dc.subjectLeukemia, Radiation-Induced
dc.subjectMyelodysplastic Syndromes
dc.subjectPreleukemia
dc.subjectSequence Deletion
dc.titleA role for mitochondrial DNA in the pathogenesis of radiation-induced myelodysplasia and secondary leukemia
dc.typeReview
Files
Collections
Stellenbosch University - Scopus Tygerberg Hospital Publications