Safety of licensed vaccines in HIV-infected persons : a systematic review protocol

Kagina, Benjamin M.; Wiysonge, Charles S.; Lesosky, Maia; Madhi, Shabir A.; Hussey, Gregory D.

Safety of licensed vaccines in HIV-infected persons : a systematic review protocol

dc.contributor.author	Kagina, Benjamin M.	en_ZA
dc.contributor.author	Wiysonge, Charles S.	en_ZA
dc.contributor.author	Lesosky, Maia	en_ZA
dc.contributor.author	Madhi, Shabir A.	en_ZA
dc.contributor.author	Hussey, Gregory D.	en_ZA
dc.date.accessioned	2014-09-16T10:01:24Z
dc.date.available	2014-09-16T10:01:24Z
dc.date.issued	2014-09	en_ZA
dc.date.updated	2014-09-15T03:02:44Z
dc.description	CITATION: Kagina, B.M. et al. 2014. Safety of licensed vaccines in HIV-infected persons: a systematic review protocol. Systematic Reviews, 3(1):101, doi:10.1186/2046-4053-3-101.	en_ZA
dc.description	The original publication is available at http://www.systematicreviewsjournal.com/content/3/1/101	en_ZA
dc.description.abstract	Background Safety of vaccines remains a cornerstone of building public trust on the use of these cost-effective and life-saving public health interventions. In some settings, particularly Sub-Saharan Africa, there is a high prevalence of HIV infection and a high burden of vaccine-preventable diseases. There is evidence suggesting that the immunity induced by some commonly used vaccines is not durable in HIV-infected persons, and therefore, repeated vaccination may be considered to ensure optimal vaccine-induced immunity in this population. However, some vaccines, particularly the live vaccines, may be unsafe in HIV-infected persons. There is lack of evidence on the safety profile of commonly used vaccines among HIV-infected persons. We are therefore conducting a systematic review to assess the safety profile of routine vaccines administered to HIV-infected persons. Methods/Design We will select studies conducted in any setting where licensed and effective vaccines were administered to HIV-infected persons. We will search for eligible studies in PubMed, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, Africa-Wide, PDQ-Evidence and CINAHL as well as reference lists of relevant publications. We will screen search outputs, select studies and extract data in duplicate, resolving discrepancies by discussion and consensus. Discussion Globally, immunisation is a major public health strategy to mitigate morbidity and mortality caused by various infectious disease-causing agents. In general, there are efforts to increase vaccination coverage worldwide, and for these efforts to be successful, safety of the vaccines is paramount, even among people living with HIV, who in some situations may require repeated vaccination. Results from this systematic review will be discussed in the context of the safety of routine vaccines among HIV-infected persons. From the safety perspective, we will also discuss whether repeat vaccination strategies may be feasible among HIV-infected persons. Systematic review registration PROSPERO CRD42014009794.	en_ZA
dc.description.version	Publishers' Version	en_ZA
dc.format.extent	6 pages
dc.identifier.citation	Kagina, B.M. et al. 2014. Safety of licensed vaccines in HIV-infected persons: a systematic review protocol. Systematic Reviews, 3(1):101, doi:10.1186/2046-4053-3-101.	en_ZA
dc.identifier.issn	2046-4053 (online)	en_ZA
dc.identifier.other	doi:10.1186/2046-4053-3-101	en_ZA
dc.identifier.uri	http://hdl.handle.net/10019.1/95558
dc.language.iso	en_ZA	en_ZA
dc.publisher	BioMed Central	en_ZA
dc.rights.holder	Benjamin M Kagina et al.; licensee BioMed Central Ltd.	en_ZA
dc.subject	AIDS vaccines	en_ZA
dc.subject	HIV infections -- Prevention	en_ZA
dc.subject	AIDS vaccines -- Safety measures	en_ZA
dc.title	Safety of licensed vaccines in HIV-infected persons : a systematic review protocol	en_ZA
dc.type	Article	en_ZA

Safety of licensed vaccines in HIV-infected persons : a systematic review protocol

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