The trace aminergic system : a gender-sensitive therapeutic target for IBS?

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dc.contributor.authorPretorius, Leshaen_ZA
dc.contributor.authorSmith, Carineen_ZA
dc.date.accessioned2020-10-12T10:42:34Z
dc.date.available2020-10-12T10:42:34Z
dc.date.issued2020-09-28
dc.date.updated2020-10-04T05:32:57Z
dc.descriptionCITATION: Pretorius, L. & Smith, C. 2020. The trace aminergic system : a gender-sensitive therapeutic target for IBS?. Journal of Biomedical Science, 27:95, doi:10.1186/s12929-020-00688-1.
dc.descriptionThe original publication is available at https://jbiomedsci.biomedcentral.com
dc.description.abstractDue to a lack of specific or sensitive biomarkers, drug discovery advances have been limited for individuals suffering from irritable bowel syndrome (IBS). While current therapies provide symptomatic relief, inflammation itself is relatively neglected, despite the presence of chronic immune activation and innate immune system dysfunction. Moreover, considering the microgenderome concept, gender is a significant aetiological risk factor. We believe that we have pinpointed a “missing link” that connects gender, dysbiosis, diet, and inflammation in the context of IBS, which may be manipulated as therapeutic target. The trace aminergic system is conveniently positioned at the interface of the gut microbiome, dietary nutrients and by-products, and mucosal immunity. Almost all leukocyte populations express trace amine associated receptors and significant amounts of trace amines originate from both food and the gut microbiota. Additionally, although IBS-specific data are sparse, existing data supports an interpretation in favour of a gender dependence in trace aminergic signalling. As such, trace aminergic signalling may be altered by fluctuations of especially female reproductive hormones. Utilizing a multidisciplinary approach, this review discusses potential mechanisms of actions, which include hyperreactivity of the immune system and aberrant serotonin signalling, and links outcomes to the symptomology clinically prevalent in IBS. Taken together, it is feasible that the additional level of regulation by the trace aminergic system in IBS has been overlooked, until now. As such, we suggest that components of the trace aminergic system be considered targets for future therapeutic action, with the specific focus of reducing oxidative stress and inflammation.en_ZA
dc.description.urihttps://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-020-00688-1
dc.description.versionPublisher's version
dc.format.extent19 pages : illustrations
dc.identifier.citationPretorius, L. & Smith, C. 2020. The trace aminergic system : a gender-sensitive therapeutic target for IBS?. Journal of Biomedical Science, 27:95, doi:10.1186/s12929-020-00688-1en_ZA
dc.identifier.issn1423-0127 (online)
dc.identifier.otherdoi:10.1186/s12929-020-00688-1
dc.identifier.urihttp://hdl.handle.net/10019.1/108887
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Central
dc.rights.holderAuthors retain copyright
dc.subjectAmines in the bodyen_ZA
dc.subjectGastrointestinal system -- Diseasesen_ZA
dc.subjectIrritable Bowel Syndromeen_ZA
dc.subjectOxidative stressen_ZA
dc.subjectInflammationen_ZA
dc.subjectInflammatory bowel diseasesen_ZA
dc.subjectIBD (Disease)en_ZA
dc.subjectBioinformaticsen_ZA
dc.subjectBio-informaticsen_ZA
dc.subjectChemistry, Physical and theoreticalen_ZA
dc.subjectDrug developmenten_ZA
dc.subjectMicrobiotheriaen_ZA
dc.subjectMicrobiotheriansen_ZA
dc.titleThe trace aminergic system : a gender-sensitive therapeutic target for IBS?en_ZA
dc.typeArticleen_ZA
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