Monitoring the South African National Antiretroviral Treatment Programme, 2003-2007 : the IeDEA Southern Africa collaboration

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dc.contributor.authorCornell, Morne
dc.contributor.authorTechnau, Karl
dc.contributor.authorFairall, Lara
dc.contributor.authorWood, Robin
dc.contributor.authorMoultrie, Harry
dc.contributor.authorVan Cutsem, Gilles
dc.contributor.authorGiddy, Janet
dc.contributor.authorMohapi, Lerato
dc.contributor.authorEley, Brian
dc.contributor.authorMacPhail, Patrick
dc.contributor.authorProzesky, Hans
dc.contributor.authorRabie, Helena
dc.contributor.authorDavies, Mary-Ann
dc.contributor.authorMaxwell, Nicola
dc.contributor.authorBoulle, Andrew
dc.date.accessioned2011-03-18T14:59:22Z
dc.date.available2011-03-18T14:59:22Z
dc.date.issued2009-09
dc.descriptionArticle
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractObjectives. To introduce the combined South African cohorts of the International epidemiologic Databases to Evaluate AIDS Southern Africa (IeDEA-SA) collaboration as reflecting the South African national antiretroviral treatment (ART) programme; to characterise patients accessing these services; and to describe changes in services and patients from 2003 to 2007. Design and setting. Multi-cohort study of 11 ART programmes in Gauteng, Western Cape, Free State and KwaZulu-Natal. Subjects. Adults and children (<16 years old) who initiated ART with ≥3 antiretroviral drugs before 2008. Results. Most sites were offering free treatment to adults and children in the public sector, ranging from 264 to 17 835 patients per site. Among 45 383 adults and 6 198 children combined, median age (interquartile range) was 35.0 years (29.8-41.4) and 42.5 months (14.7-82.5), respectively. Of adults, 68% were female. The median CD4 cell count was 102 cells/μl (44-164) and was lower among males than females (86, 34-150 v. 110, 50-169, p<0.001). Median CD4% among children was 12% (7-17.7). Between 2003 and 2007, enrolment increased 11-fold in adults and 3-fold in children. Median CD4 count at enrolment increased for all adults (67-111 cells/μl, p<0.001) and for those in stage IV (39-89 cells/μl, p<0.001). Among children <5 years, baseline CD4% increased over time (11.5-16.0%, p<0.001). Conclusions. IeDEA-SA provides a unique opportunity to report on the national ART programme. The study describes dramatically increased enrolment over time. Late diagnosis and ART initiation, especially of men and children, need attention. Investment in sentinel sites will ensure good individual-level data while freeing most sites to continue with simplified reporting.
dc.description.versionPublishers’ Version
dc.format.extentp. 653-660
dc.identifier.citationCornell, M. et al. 2009. Monitoring the South African National Antiretroviral Treatment Programme, 2003-2007: The IeDEA Southern Africa collaboration. South African Medical Journal, 99(9):653-660.
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7791
dc.language.isoen_ZA
dc.publisherHealth and Medical Publishing Group (HMPG)
dc.rights.holderSAMJ reserves copyright of the material published
dc.subjectHIV infections -- Treatment -- South Africaen_ZA
dc.subjectAIDS (Disease) -- Treatment -- South Africaen_ZA
dc.subjectSouth African National Antiretroviral Treatment Programmeen_ZA
dc.titleMonitoring the South African National Antiretroviral Treatment Programme, 2003-2007 : the IeDEA Southern Africa collaborationen_ZA
dc.typeArticle
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