Neurological soft signs, spontaneous and treatment emergent extrapyramidal syndromes in Black Africans with first episode schizophrenia

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dc.contributor.authorOjagbemi, Akinen_ZA
dc.contributor.authorChiliza, Bongaen_ZA
dc.contributor.authorBello, Toyinen_ZA
dc.contributor.authorAsmal, Lailaen_ZA
dc.contributor.authorEsan, Oluyomien_ZA
dc.contributor.authorEmsley, Robin A.en_ZA
dc.contributor.authorGureje, Oyeen_ZA
dc.date.accessioned2020-04-10T07:00:13Z
dc.date.available2020-04-10T07:00:13Z
dc.date.issued2018
dc.descriptionCITATION: Ojagbemi, A., et al. 2018. Neurological soft signs, spontaneous and treatment emergent extrapyramidal syndromes in Black Africans with first episode schizophrenia. Frontiers in Psychiatry, 9:172, doi:10.3389/fpsyt.2018.00172.
dc.descriptionThe original publication is available at https://www.frontiersin.org
dc.description.abstractBackground: Very little is known about the relationship between spontaneous and treatment-induced motor syndromes in Africans with first episode schizophrenia. Objective: We investigated the association between spontaneous NSS and EPS, with treatment-induced EPS in a homogenous sample of Black Africans with first episode schizophrenia. Methods: We examined Xhosa (South Africa) and Yoruba (Nigeria) patients, using the Neurological Evaluation Scale and extrapyramidal symptoms scale before and at 3 months after exposure to low dose flupenthixol decanoate. Pearson's correlations and Linear regression models, controlling for duration of untreated psychosis (D.U.P) and premorbid adjustments, were used in examining associations. Results: Among 99 participants in the baseline sample, 91 (91.8%) and 20 (20.2%) had at least one definite NSS and EPS, respectively, before exposure to antipsychotics. Treatment-induced EPS were recorded in 34 (38.6%). Spontaneous EPS was associated with treatment-emergent Akathisia in participants with a longer D.U.P (r = 0.75, β = 0.70, p = 0.008). This association was specific for Parkinsonism (r = 0.75, β = 0.85, p = 0.008) and dyskinesia (r = 0.75, β = 1.70, p = 0.008). Conclusion: Similar to previous findings for tardive dyskinesia in studies implementing longer-term follow-up, spontaneous EPS may also predict short-term antipsychotic-induced EPS such as akathisia. These results may be important for early identification of patients at risk of treatment-induced Akathisia-linked psychomotor agitation in first episode schizophrenia.en_ZA
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fpsyt.2018.00172/full
dc.description.versionPublisher's version
dc.format.extent7 pages ; illustrations
dc.identifier.citationOjagbemi, A., et al. 2018. Neurological soft signs, spontaneous and treatment emergent extrapyramidal syndromes in Black Africans with first episode schizophrenia. Frontiers in Psychiatry, 9:172, doi:10.3389/fpsyt.2018.00172
dc.identifier.issn1664-0640 (online)
dc.identifier.otherdoi:10.3389/fpsyt.2018.00172
dc.identifier.urihttp://hdl.handle.net/10019.1/107679
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Media
dc.rights.holderAuthors retain copyright
dc.subjectNeurologic examinationen_ZA
dc.subjectBlacks -- Africaen_ZA
dc.subjectExtrapyramidal disordersen_ZA
dc.titleNeurological soft signs, spontaneous and treatment emergent extrapyramidal syndromes in Black Africans with first episode schizophreniaen_ZA
dc.typeArticleen_ZA
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