Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans : a cross sectional study

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dc.contributor.authorOmuse, Geoffreyen_ZA
dc.contributor.authorMaina, Danielen_ZA
dc.contributor.authorMwangi, Janeen_ZA
dc.contributor.authorWambua, Carolineen_ZA
dc.contributor.authorKanyua, Aliceen_ZA
dc.contributor.authorKagotho, Elizabethen_ZA
dc.contributor.authorAmayo, Angelaen_ZA
dc.contributor.authorOjwang, Peteren_ZA
dc.contributor.authorErasmus, Rajiven_ZA
dc.date.accessioned2018-01-05T10:04:00Z
dc.date.available2018-01-05T10:04:00Z
dc.date.issued2017-12-20
dc.date.updated2017-12-24T04:17:23Z
dc.descriptionCITATION: Omuse, G. et al. 2017. Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans : a cross sectional study. BMC Nephrology, 18:369, doi:10.1186/s12882-017-0788-y.
dc.descriptionThe original publication is available at https://bmcnephrol.biomedcentral.com
dc.description.abstractBackground: Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease (CKD). Some of the equations provide a correction factor for African-Americans due to their relatively increased muscle mass and this has been extrapolated to black Africans. Studies carried out in Africa in patients with CKD suggest that using this correction factor for the black African race may not be appropriate. However, these studies were not carried out in healthy individuals and as such the extrapolation of the findings to an asymptomatic black African population is questionable. We sought to compare the proportion of asymptomatic black Africans reported as having reduced eGFR using various eGFR equations. We further compared the association between known risk factors for CKD with eGFR determined using the different equations. Methods: We used participant and laboratory data collected as part of a global reference interval study conducted by the Committee of Reference Intervals and Decision Limits (C-RIDL) under the International Federation of Clinical Chemistry (IFCC). Serum creatinine values were used to calculate eGFR using the Cockcroft-Gault (CG), re-expressed 4 variable modified diet in renal disease (4v–MDRD), full age spectrum (FAS) and chronic kidney disease epidemiology collaboration equations (CKD-EPI). CKD classification based on eGFR was determined for every participant. Results: A total of 533 participants were included comprising 273 (51.2%) females. The 4v–MDRD equation without correction for race classified the least number of participants (61.7%) as having an eGFR equivalent to CKD stage G1 compared to 93.6% for CKD-EPI with correction for race. Only age had a statistically significant linear association with eGFR across all equations after performing multiple regression analysis. The multiple correlation coefficients for CKD risk factors were higher for CKD-EPI determined eGFRs. Conclusions: This study found that eGFR determined using CKD-EPI equations better correlated with a prediction model that included risk factors for CKD and classified fewer asymptomatic black Africans as having a reduced eGFR compared to 4v–MDRD, FAS and CG corrected for body surface area.
dc.description.urihttps://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-017-0788-y
dc.description.versionPublisher's version
dc.format.extent8 pages
dc.identifier.citationOmuse, G. et al. 2017. Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans : a cross sectional study. BMC Nephrology, 18:369, doi:10.1186/s12882-017-0788-y.
dc.identifier.issn1471-2369 (online)
dc.identifier.otherdoi:10.1186/s12882-017-0788-y
dc.identifier.urihttp://hdl.handle.net/10019.1/103025
dc.language.isoen
dc.publisherBioMed Central
dc.rights.holderAuthors retain copyright
dc.subjectChronic renal failureen_ZA
dc.subjectKidneys -- Diseasesen_ZA
dc.subjectNephrologyen_ZA
dc.subjectGlomerular filtration rateen_ZA
dc.titleComparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans : a cross sectional studyen_ZA
dc.typeArticle
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