IL-22 : an underestimated player in natural resistance to tuberculosis?

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dc.contributor.authorRonacher, Katharinaen_ZA
dc.contributor.authorSinha, Romaen_ZA
dc.contributor.authorCestari, Michelleen_ZA
dc.date.accessioned2019-09-23T11:53:14Z
dc.date.available2019-09-23T11:53:14Z
dc.date.issued2018
dc.descriptionCITATION: Ronacher, K., Sinha, R. & Cestari, M. 2018. IL-22 : an underestimated player in natural resistance to tuberculosis?. Frontiers in Immunology, 9:2209, doi:10.3389/fimmu.2018.02209
dc.descriptionThe original publication is available at https://www.frontiersin.org
dc.description.abstractENGLISH ABSTRACT: Approximately 10% of individuals latently infected with Mycobacterium tuberculosis (Mtb) develop active tuberculosis (TB) during their lifetime. Although it is well recognized that T-helper 1 immune responses are crucial for containing latent TB infection, the full array of host factors conferring protective immunity from TB progression are not completely understood. IL-22 is produced by cells of the innate and adaptive immune system including innate lymphoid cells, and natural killer cells as well as T lymphocytes (Th1, Th17, and Th22) and binds to its cognate receptor, the IL-22R1, which is expressed on non-hematopoietic cells such as lung epithelial cells. However, recent studies suggest that Mtb induces expression of the IL-22R1 on infected macrophages and multiple studies have indicated a protective role of IL-22 in respiratory tract infections. Reduced concentrations of circulating IL-22 in active TB compared to latent TB and decreased percentages of Mtb-specific IL-22 producing T cells in TB patients compared to controls designate this cytokine as a key player in TB immunology. More recently, it has been shown that in type 2 diabetes (T2D) and TB co-morbidity serum IL-22 concentrations are further reduced compared to TB patients without co-morbidities. However, whether a causative link between low IL-22 and increased susceptibility to TB and disease severity of TB exists remains to be established. This review summarizes the contribution of IL-22, a potentially under-appreciated key player in natural resistance to TB, at the interface between the immune response to Mtb and the lung epithelium.en_ZA
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2018.02209/full
dc.description.versionPublisher's version
dc.format.extent7 pagesen_ZA
dc.identifier.citationRonacher, K., Sinha, R. & Cestari, M. 2018. IL-22 : an underestimated player in natural resistance to tuberculosis?. Frontiers in Immunology, 9:2209, doi:10.3389/fimmu.2018.02209
dc.identifier.issn1664-3224 (online)
dc.identifier.otherdoi:10.3389/fimmu.2018.02209
dc.identifier.urihttp://hdl.handle.net/10019.1/106516
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Mediaen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTuberculosisen_ZA
dc.subjectMycobacterium tuberculosisen_ZA
dc.subjectT lymphocytesen_ZA
dc.titleIL-22 : an underestimated player in natural resistance to tuberculosis?en_ZA
dc.typeArticleen_ZA
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