Dietary impact on neuronal autophagy control and brain health

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dc.contributor.authorNtsapi, Claudiaen_ZA
dc.contributor.authorDu Toit, Andreen_ZA
dc.contributor.authorLoos, Benen_ZA
dc.date.accessioned2019-06-20T09:11:29Z
dc.date.available2019-06-20T09:11:29Z
dc.date.issued2019
dc.descriptionCITATION: Ntsapi, C., Du Toit, A. & Loos, B. 2019. Dietary impact on neuronal autophagy control and brain health. In: Bosch-Bouju, C., Laye, S. & Pallet, V. (eds.) Feed your mind - how does nutrition modulate brain function throughout life?. IntechOpen, doi:10.5772/intechopen.85228.en_ZA
dc.descriptionThe original publication is available at https://www.intechopen.comen_ZA
dc.descriptionPublication of this chapter was funded by the Stellenbosch University Open Access Fund.en_ZA
dc.description.abstractAutophagy is the major intracellular system which is critical for the removal of harmful protein aggregates and malfunctioning organelles. Dysfunctional autophagy is associated with a multitude of human diseases, such as protein aggregation in Alzheimer’s disease and non-successful aging. Major interest exists in the dietary manipulation of the autophagy pathway activity, so as to tune the cell’s protein degradation capabilities and to prevent cell death onset. It has recently become clear that the machinery required to degrade protein cargo has a distinct activity level which can be altered through specific dietary modulation. Moreover, this activity may differ from that of the proteinaceous cargo. Overall, brain health and successful aging are characterized by limited protein aggregation, with a distinct molecular signature of maintained autophagy function. However, it is largely unclear how to control autophagy through dietary interventions with a precision that would allow to maintain minimal levels of toxic proteins, preserving neuronal cell viability and proteostasis. In this chapter, we carefully dissect the relationship between autophagy- modulating drugs, including caloric restriction mimetics and their impact on neuronal autophagy, in the context of preserving brain health.en_ZA
dc.description.urihttps://www.intechopen.com/online-first/dietary-impact-on-neuronal-autophagy-control-and-brain-health
dc.description.versionPublisher's versionen_ZA
dc.format.extent21 pages : illustrationsen_ZA
dc.identifier.citationNtsapi, C., Du Toit, A. & Loos, B. 2019. Dietary impact on neuronal autophagy control and brain health. In: Bosch-Bouju, C., Laye, S. & Pallet, V. (eds.) Feed your mind - how does nutrition modulate brain function throughout life?. IntechOpen, doi:10.5772/intechopen.85228en_ZA
dc.identifier.otherdoi:10.5772/intechopen.85228
dc.identifier.urihttp://hdl.handle.net/10019.1/106282
dc.language.isoen_ZAen_ZA
dc.publisherIntechOpenen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectAutophagic fluxen_ZA
dc.subjectNeurodegenerationen_ZA
dc.subjectNeuronal autophagyen_ZA
dc.subjectNervous system -- Degeneration -- Diet therapyen_ZA
dc.subjectNervous system -- Degeneration -- Alternative treatmenten_ZA
dc.titleDietary impact on neuronal autophagy control and brain healthen_ZA
dc.typeChapters in Booksen_ZA
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