Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

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dc.contributor.authorMalherbe, Stephanus T.en_ZA
dc.contributor.authorChen, Ray Y.en_ZA
dc.contributor.authorDupont, Patricken_ZA
dc.contributor.authorKant, Ilseen_ZA
dc.contributor.authorKriel, Magdalenaen_ZA
dc.contributor.authorLoxton, Andre G.en_ZA
dc.contributor.authorSmith, Bronwynen_ZA
dc.contributor.authorBeltran, Caroline G. G.en_ZA
dc.contributor.authorVan Zyl, Susanen_ZA
dc.contributor.authorMcAnda, Shirelyen_ZA
dc.contributor.authorAbrahams, Charmaineen_ZA
dc.contributor.authorMaasdorp, Eliznaen_ZA
dc.contributor.authorDoruyter, Alexen_ZA
dc.contributor.authorVia, Laura E.en_ZA
dc.contributor.authorBarry, Clifton E.en_ZA
dc.contributor.authorAlland, Daviden_ZA
dc.contributor.authorGriffith- Richards, Stephanieen_ZA
dc.contributor.authorEllman, Annareen_ZA
dc.contributor.authorPeppard, Thomasen_ZA
dc.contributor.authorBelisle, Johnen_ZA
dc.contributor.authorTromp, Gerarden_ZA
dc.contributor.authorRonacher, Katharinaen_ZA
dc.contributor.authorWarwick, James M.en_ZA
dc.contributor.authorWinter, Jillen_ZA
dc.contributor.authorWalzl, Gerharden_ZA
dc.date.accessioned2021-01-22T13:51:06Z
dc.date.available2021-01-22T13:51:06Z
dc.date.issued2020
dc.descriptionCITATION: Malherbe, S. T., et al. 2020. Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response. EJNMMI Research, 10:8, doi:10.1186/s13550-020-0591-9.
dc.descriptionThe original publication is available at https://ejnmmires.springeropen.com
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund
dc.description.abstractBackground: There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic activity after apparent clinical cure. This poses a challenge in quantifying scan-based markers of burden of disease and disease activity. We used semi-automated, whole lung quantification of lung lesions to analyse serial FDG PET-CT scans from the Catalysis TB Treatment Response Cohort to identify characteristics that best correlated with clinical and microbiological outcomes. Results: Quantified scan metrics were already associated with clinical outcomes at diagnosis and 1 month after treatment, with further improved accuracy to differentiate clinical outcomes after standard treatment duration (month 6). A high cavity volume showed the strongest association with a risk of treatment failure (AUC 0.81 to predict failure at diagnosis), while a suboptimal reduction of the total glycolytic activity in lung lesions during treatment had the strongest association with recurrent disease (AUC 0.8 to predict pooled unfavourable outcomes). During the first year after TB treatment lesion burden reduced; but for many patients, there were continued dynamic changes of individual lesions. Conclusions: Quantification of FDG PET-CT images better characterised TB treatment outcomes than qualitative scan patterns and robustly measured the burden of disease. In future, validated metrics may be used to stratify patients and help evaluate the effectiveness of TB treatment modalities.en_ZA
dc.description.urihttps://ejnmmires.springeropen.com/articles/10.1186/s13550-020-0591-9#citeas
dc.description.versionPublisher's version
dc.format.extent15 pagesen_ZA
dc.identifier.citationMalherbe, S. T., et al. 2020. Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response. EJNMMI Research, 10:8, doi:10.1186/s13550-020-0591-9
dc.identifier.issn2191-219X (online)
dc.identifier.otherdoi:10.1186/s13550-020-0591-9
dc.identifier.urihttp://hdl.handle.net/10019.1/109014
dc.language.isoen_ZAen_ZA
dc.publisherSpringerOpen (part of Springer Nature)en_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTuberculosis -- Treatmenten_ZA
dc.subjectTuberculostatic agentsen_ZA
dc.subjectComplications of therapyen_ZA
dc.subjectQuantitative analysisen_ZA
dc.subjectDiseases -- Imagingen_ZA
dc.titleQuantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment responseen_ZA
dc.typeArticleen_ZA
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