Otorrhoea is a marker for symptomatic disease in HIV-infected children

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dc.contributor.authorKarpakis, J.
dc.contributor.authorRabie, H.
dc.contributor.authorHoward, J.
dc.contributor.authorVan Rensburg, A. J.
dc.contributor.authorCotton, M. F.
dc.date.accessioned2011-03-18T14:56:55Z
dc.date.available2011-03-18T14:56:55Z
dc.date.issued2007
dc.descriptionArticle
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractBackground. Chronic otorrhoea occurs commonly in HIV-infected children. However, there are few data on incidence and severity. Objective. To document the prevalence of otorrhoea in the clinic attendees. Methods. A retrospective chart review was done of all HIV-I infected children seen at the Family Clinic for HIV from 1 February 1997 to 31 December 2001, a period preceding widespread availability of antiretrovirals: Otorrhoea was classified into two groups, viz. group 1 (mild): an episode lasting less than 1 month, and group 2 (severe): an episode lasting more than 1 month or more than 1 episode of otorrhoea. The clinical and immune stages of the children were noted. Results. Of 326 children seen during the study period, 104 (32%) had otorrhoea. Forty-five (13.8%) had mild and 59 (18.1%) severe otorrhoea. Two hundred and eighty-eight (88.6%) had either Centers for Disease Control stage B or C disease. The median CD4 percentage in children with otorrhoea was 17.5% (8.3 - 23%) versus 21% (14 - 28%) in those without otorrhoea (p=0.004). The odds ratio (OR) of children in stage B or C not having severe otorrhoea was 0.1 (0.01 - 0.72, p = 0.013). The OR for immune class 2 or 3 without severe otorrhoea was 0.39 (0.18 - 0.85, p = 0.021). Conclusions. Otorrhoea contributes to the morbidity of HIV infection in children. It is a marker for symptomatic disease and CD4 depletion and should be included in clinical classification.en
dc.format.extentp. 1292-1294
dc.identifier.citationKarpakis, J. et.al. 2007. Otorrhoea is a marker for symptomatic disease in HIV-infected children, South African Medical Journal, 97(12) 1292-1294, http://www.samj.org.za/index.php/samj
dc.identifier.issn02569574 (print)
dc.identifier.issn20785135 (online)
dc.identifier.urihttp://hdl.handle.net/10019.1/7069
dc.language.isoen_US
dc.publisherHealth and Medical Publishing Group (HMPG)
dc.rights.holderHealth and Medical Publishing Group (HMPG)
dc.subjectOtorrhoeaen
dc.subjectHIV in children -- Diagnosis
dc.titleOtorrhoea is a marker for symptomatic disease in HIV-infected childrenen
dc.typeArticle
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