Mitochondrial DNA is unsuitable to test for isolation by distance

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dc.contributor.authorTeske, Peter R.en_ZA
dc.contributor.authorGolla, Tirupathi Raoen_ZA
dc.contributor.authorSandoval-Castillo, Jonathanen_ZA
dc.contributor.authorEmami-Khoyi, Arsalanen_ZA
dc.contributor.authorVan der Lingen, Carl D.en_ZA
dc.contributor.authorVon der Heyden, Sophieen_ZA
dc.contributor.authorChiazzari, Brenten_ZA
dc.contributor.authorVan Vuuren, Bettine Jansenen_ZA
dc.contributor.authorBeheregaray, Luciano B.en_ZA
dc.date.accessioned2020-03-12T10:30:50Z
dc.date.available2020-03-12T10:30:50Z
dc.date.issued2018-05-31
dc.descriptionCITATION: Teske, P. R., et al. 2018. Mitochondrial DNA is unsuitable to test for isolation by distance. Scientific Reports, 8:8448, doi:10.1038/s41598-018-25138-9.
dc.descriptionThe original publication is available at https://www.nature.com
dc.description.abstractTests for isolation by distance (IBD) are the most commonly used method of assessing spatial genetic structure. Many studies have exclusively used mitochondrial DNA (mtDNA) sequences to test for IBD, but this marker is often in conflict with multilocus markers. Here, we report a review of the literature on IBD, with the aims of determining (a) whether significant IBD is primarily a result of lumping spatially discrete populations, and (b) whether microsatellite datasets are more likely to detect IBD when mtDNA does not. We also provide empirical data from four species in which mtDNA failed to detect IBD by comparing these with microsatellite and SNP data. Our results confirm that IBD is mostly found when distinct regional populations are pooled, and this trend disappears when each is analysed separately. Discrepancies between markers were found in almost half of the studies reviewed, and microsatellites were more likely to detect IBD when mtDNA did not. Our empirical data rejected the lack of IBD in the four species studied, and support for IBD was particularly strong for the SNP data. We conclude that mtDNA sequence data are often not suitable to test for IBD, and can be misleading about species’ true dispersal potential. The observed failure of mtDNA to reliably detect IBD, in addition to being a single-locus marker, is likely a result of a selection-driven reduction in genetic diversity obscuring spatial genetic differentiation.en_ZA
dc.description.urihttps://www.nature.com/articles/s41598-018-25138-9/
dc.description.versionPublisher's version
dc.format.extent9 pages : illustrationsen_ZA
dc.identifier.citationTeske, P. R., et al. 2018. Mitochondrial DNA is unsuitable to test for isolation by distance. Scientific Reports, 8:8448, doi:10.1038/s41598-018-25138-9
dc.identifier.issn2045-2322 (online)
dc.identifier.otherdoi:10.1038/s41598-018-25138-9
dc.identifier.urihttp://hdl.handle.net/10019.1/107616
dc.language.isoen_ZAen_ZA
dc.publisherNature Research
dc.rights.holderAuthors retain copyright
dc.subjectMitochondrial DNA -- Analysisen_ZA
dc.subjectIsolation by distanceen_ZA
dc.subjectMicrosatellites (Genetics)en_ZA
dc.titleMitochondrial DNA is unsuitable to test for isolation by distanceen_ZA
dc.typeArticleen_ZA
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