Observed HIV drug resistance associated mutations amongst naïve immunocompetent children in Yaounde, Cameroon

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dc.contributor.authorIkomey, George Mondindeen_ZA
dc.contributor.authorAssoumou, Marie Claire Okomoen_ZA
dc.contributor.authorGichana, Josiah Otwomaen_ZA
dc.contributor.authorNjenda, Duncanen_ZA
dc.contributor.authorMikasi, Sello Givenen_ZA
dc.contributor.authorMesembe, Marthaen_ZA
dc.contributor.authorLyonga, Emiliaen_ZA
dc.contributor.authorJacobs, Graeme Brendonen_ZA
dc.date.accessioned2018-08-29T06:32:21Z
dc.date.available2018-08-29T06:32:21Z
dc.date.issued2017
dc.descriptionCITATION: Ikomey, G. M., et al. 2017. Observed HIV drug resistance associated mutations amongst naïve immunocompetent children in Yaounde, Cameroon. GERMS, 7(4):178-185, doi:10.18683/germs.2017.1124.
dc.descriptionThe original publication is available at http://www.germs.ro/en/Homepage/
dc.description.abstractIntroduction: The emergence of drug resistance mutations (DRMs) has been a major threat for successful lifelong combination antiretroviral therapy (cART), especially for HIV-vertically infected children within the context of the prevention of mother-to-child transmission (PMTCT). This study aimed to evaluate DRMs amongst immune competent treatment-naïve children in Cameroon. Methods: A cross-sectional study was conducted between 2015 and 2016 amongst 55 proxy consented HIV-1 positive children, aged 9 months to 6 years. They were all immune competent, cART naïve and with unknown history of PMTCT. CD4 cell counts and genotypic drug resistance testing were performed using standard methods. Results: Levels of DRMs to protease (PR) inhibitors (PIs), nucleoside reverse transcriptase inhibitors (NRTIs) and non-NRTIs were 27.6%, 3.7% and 40.7%, respectively. Only minor DRMs were observed for PR. The observed mutations for NRTI were K65R, T215I and K219E (33.0% each) and for NNRTI: V106M, Y181C and Y188H (6.0% each). Only minor accessory mutations were found in the integrase (IN) region. Conclusion: Despite widely available cART we still observe naïve HIV children, especially from the rural communities. We observe that a proportion of study participants had HIV-1 drug resistance associated mutations (RAMs). Data generated could help strengthen the current PMTCT programmes within the country. There is a need to upscale approaches for drug resistance testing for children in Cameroon and many other resource-limited settings.en_ZA
dc.description.urihttp://www.germs.ro/en/Articles/Observed-HIV-drug-resistance-associated-mutations-amongst-na%C3%AFve-immunocompetent-children-in-Yaound%C3%A9-Cameroon-702
dc.description.versionPublisher's version
dc.format.extent8 pages
dc.identifier.citationIkomey, G. M., et al. 2017. Observed HIV drug resistance associated mutations amongst naïve immunocompetent children in Yaounde, Cameroon. GERMS, 7(4):178-185, doi:10.18683/germs.2017.1124
dc.identifier.issn2248-2997 (online)
dc.identifier.otherdoi:10.18683/germs.2017.1124
dc.identifier.urihttp://hdl.handle.net/10019.1/104360
dc.language.isoen_ZAen_ZA
dc.publisherEuropean HIV/AIDS and Infectious Diseases Academy
dc.rights.holderEuropean HIV/AIDS and Infectious Diseases Academy
dc.subjectHighly active antiretroviral therapyen_ZA
dc.subjectHIV-positive childrenen_ZA
dc.titleObserved HIV drug resistance associated mutations amongst naïve immunocompetent children in Yaounde, Cameroonen_ZA
dc.typeArticleen_ZA
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