Expectant management of early onset, severe pre-eclampsia: Maternal outcome

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dc.contributor.authorHall D.R.
dc.contributor.authorOdendaal H.J.
dc.contributor.authorSteyn D.W.
dc.contributor.authorGrove D.
dc.date.accessioned2011-05-15T16:15:47Z
dc.date.available2011-05-15T16:15:47Z
dc.date.issued2000
dc.description.abstractObjective. To evaluate the safety and outcome of women undergoing expectant management of early onset, severe pre-eclampsia. Design. Prospective case series extending over a five-year period. Setting. Tygerberg Hospital, a tertiary referral centre. Population. All women (n = 340) presenting with early onset, severe pre-eclampsia, where both the mother and the fetus were otherwise stable. Methods. Frequent clinical and biochemical monitoring of maternal status, together with careful blood pressure control, in a high care obstetric ward. Main outcome measures. Major maternal complications and prolongation of gestation. Results: Multigravid women constituted 67% of the group. Antenatal biochemistry was reassuring with some expected, but not severe, deteriorations. Twenty-seven percent of women experienced a major complication, but few had poor outcomes. No maternal deaths occurred. Most major complications resolved quickly, necessitating only three admissions (0.8%) to the intensive care unit. One woman required dialysis. Pregnancies were prolonged by a mean (median) number of 11 days (9) before delivery, with more time being gained at earlier gestations. The postpartum inpatient stay (89% ≤ 7 days, bearing in mind that 82% of women were delivered by caesarean section) was not extended. Conclusion. Careful noninvasive management of early onset, severe pre-eclampsia in a tertiary centre can diminish and limit the impact of serious maternal complications. Valuable time to prolong the pregnancy and improve neonatal outcome is thereby gained.
dc.description.versionArticle
dc.identifier.citationBritish Journal of Obstetrics and Gynaecology
dc.identifier.citation107
dc.identifier.citation10
dc.identifier.issn03065456
dc.identifier.urihttp://hdl.handle.net/10019.1/13492
dc.subjectarticle
dc.subjectblood pressure regulation
dc.subjectfemale
dc.subjectfetus distress
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectonset age
dc.subjectpatient monitoring
dc.subjectpreeclampsia
dc.subjectpriority journal
dc.subjecttreatment outcome
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAntihypertensive Agents
dc.subjectCalcium Channel Blockers
dc.subjectDihydralazine
dc.subjectFemale
dc.subjectFetal Distress
dc.subjectHuman
dc.subjectMagnesium Sulfate
dc.subjectMethyldopa
dc.subjectMonitoring, Physiologic
dc.subjectNifedipine
dc.subjectPrazosin
dc.subjectPre-Eclampsia
dc.subjectPregnancy
dc.subjectPregnancy Outcome
dc.subjectProspective Studies
dc.subjectSupport, Non-U.S. Gov't
dc.titleExpectant management of early onset, severe pre-eclampsia: Maternal outcome
dc.typeArticle
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