Proposed mechanisms for the anabolic steriod-induced increase in myocardial susceptibility to ischaemia/reperfusion injury
dc.contributor.author | Du Toit, E. F. | |
dc.contributor.author | Rossouw, E. | |
dc.contributor.author | Van Rooyen, J. | |
dc.contributor.author | Lochner, A. | |
dc.date.accessioned | 2012-01-23T14:30:49Z | |
dc.date.available | 2012-01-23T14:30:49Z | |
dc.date.issued | 2005-02 | |
dc.description | The original publication is available at http://www.cvja.co.za/ | en_ZA |
dc.description | Includes bibliography. | |
dc.description.abstract | Androgenic anabolic steroids (AAS) are often used by athletes to enhance athletic performance but are strongly associated with detrimental cardiovascular effects including sudden cardiac death. Hypothesis: AAS use increases myocardial susceptibility to ischaemia/reperfusion injury. Methods: Rats were trained (swimming) with or without intramuscular injection of nandrolone laurate (0.375 mg/kg). Untrained rats with or without nandrolone served as controls. Hearts were mounted on the Langendorff perfusion apparatus and mechanical function was measured before and after 20-min normothermic global ischaemia. Myocardial tissue samples were collected for determination of tissue cyclic nucleotide and TNFα concentrations. Results: Anabolic steroids decreased the rate pressure product (RPP) of the exercise-trained rat heart [34 582 ± 1 778 mmHg/min vs 28 868 ± 2 446 mmHg/min for exercise-trained steroid-treated hearts (p < 0.05)]. Reperfusion RPP was lower in both the sedentary, and the exercise-trained, steroid-treated hearts than in their concurrent vehicle-treated controls (18 276 ± 2 026 mmHg/min vs 12 018 ± 1 725 mmHg/min for sedentary steroid-treated hearts and, 21 892 ± 2 912 mmHg vs 12 838 ± 1 536 mmHg/min for exercise-trained steroidtreated hearts). Myocardial TNFα [267.75 ± 44.25 pg/g vs 190.00 ± 15.75 pg/g (p < 0.05)] and cAMP concentrations [406.04 ± 18.41 pmol/g vs 235.6 ± 43.26 pmol/g | en_ZA |
dc.description.version | Publishers' version | en_ZA |
dc.format.extent | p. 21-28 : ill. | |
dc.identifier.citation | Du Toit, E.F., Rossouw, E., Van Rooyen, J. & Lochner, A. 2005. Proposed mechanisms for the anabolic steriod-induced increase in myocardial susceptibility to ischaemia/reperfusion injury. Cardiovascular Journal of South Africa, 16(1), 21-28 | en_ZA |
dc.identifier.issn | 1680-0745 (online) | |
dc.identifier.issn | 1995-1892 (print) | |
dc.identifier.uri | http://hdl.handle.net/10019.1/19350 | |
dc.language.iso | en_ZA | en_ZA |
dc.publisher | Clinics Cardiv Publishing | en_ZA |
dc.rights.holder | Cardiovascular Journal of Africa holds the copyright | en_ZA |
dc.subject | Anabolic steriods | en_ZA |
dc.subject | Athletic performance | en_ZA |
dc.subject | Cardiovascular effects | en_ZA |
dc.subject | Cardiovascular diseases -- Mortality | |
dc.subject | Cardiovascular diseases -- Effect of anabolic steroids on | |
dc.title | Proposed mechanisms for the anabolic steriod-induced increase in myocardial susceptibility to ischaemia/reperfusion injury | en_ZA |
dc.type | Article | en_ZA |