In vitro analysis of the combinatory effects of novel aminonaphthoquinone derivatives and curcumin on breast cancer progression

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dc.contributor.authorPereira, Melanie C.en_ZA
dc.contributor.authorMohammed, Raushaanen_ZA
dc.contributor.authorVan Otterlo, Willem A. L.en_ZA
dc.contributor.authorDe Koning, Charles B.en_ZA
dc.contributor.authorDavids, Hajierahen_ZA
dc.date.accessioned2022-04-29T07:37:23Z
dc.date.available2022-04-29T07:37:23Z
dc.date.issued2020-01
dc.descriptionCITATION: Pereira, Melanie C. et al. 2020. In vitro analysis of the combinatory effects of novel aminonaphthoquinone derivatives and curcumin on breast cancer progression. Anticancer Research, 40(1):229-238, doi:10.21873/anticanres.13944.en_ZA
dc.descriptionThe original publication is available at: https://pubmed.ncbi.nlm.nih.gov
dc.description.abstractBackground/aim: We previously reported the potential of aminonaphthoquinone derivatives as therapeutic agents against breast and other oestrogen-responsive tumours when combined with curcumin. This study aimed at screening of novel aminonaphthoquinone derivatives (Rau 008, Rau 010, Rau 015 and Rau 018) combined with curcumin for cytotoxic, anti-angiogenic and anti-metastatic effects on MCF-7 and MDA-MB-231 breast cancer cells. Materials and methods: Cytotoxic and anti-angiogenic effects were analysed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and enzyme-linked immunosorbent assay; while anti-metastatic effects were measured using adhesion assay, Boyden chambers and Matrigel. Results: Curcumin combined with Rau 008 elicited marked cytotoxic effects in MCF-7 cells compared with the individual treatments, whereas when it was combined with Rau 015 and with Rau 018, it displayed similar effects in MDA-MB-231 cells. The anti-angiogenic effect of Rau 015 plus curcumin in MCF-7 cells and Rau 018 plus curcumin in MDA-MB-231 cells was more effective than individual treatments, while the metastatic capability of MDA-MB-231 cells was significantly reduced after treatment with the aminonaphthoquinone-curcumin combinations. Conclusion: Aminonaphthoquinones may offer significant promise as therapeutic agents against breast cancer, particularly when combined with curcumin.en_ZA
dc.description.versionPublisher's version
dc.format.extent10 pagesen_ZA
dc.identifier.citationPereira, Melanie C. et al. 2020. In vitro analysis of the combinatory effects of novel aminonaphthoquinone derivatives and curcumin on breast cancer progression. Anticancer Research, 40(1):229-238, doi:10.21873/anticanres.13944en_ZA
dc.identifier.otherdoi:10.21873/anticanres.13944
dc.identifier.urihttp://hdl.handle.net/10019.1/124485
dc.language.isoen_ZAen_ZA
dc.publisherInternational Institute of Anticancer Researchen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectAminonaphthoquinoneen_ZA
dc.subjectAngiogenic proteinsen_ZA
dc.subjectMetastatic canceren_ZA
dc.subjectCurcuminen_ZA
dc.subjectAnticancer antibioticsen_ZA
dc.subjectCytotoxic antibioticsen_ZA
dc.titleIn vitro analysis of the combinatory effects of novel aminonaphthoquinone derivatives and curcumin on breast cancer progressionen_ZA
dc.typeArticleen_ZA
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