Epidural and intramuscular pethidine - a pharmacokinetic study
Date
1983-02
Authors
Payne, K. A.
Journal Title
Journal ISSN
Volume Title
Publisher
Health and Medical Publishing Group -- HMPG
Abstract
Epidural preservative-free pethidine hydrochloride 0,75 mg/kg is rapidly absorbed into the blood. At 1,5 mg/kg the plasma levels reached are similar to those achieved by intramuscular preservative-free pethidine hydrochloride, as is the time course. Plasma levels fall more rapidly after epidural pethidine. Since the plasma levels lag behind the analgesic effects, they are unlikely to be of importance as regards clinical analgesia.
Description
The original publication is available at http://www.samj.org.za
Keywords
Epidural pethidine, Intramuscular pethidine
Citation
Payne, K. A. 1983. Epidural and intramuscular pethidine - a pharmacokinetic study. South African Medical Journal, 5 February: 193-196.