Clinical experience with Repotin, a locally produced recombinant human erythropoietin, in the treatment of anaemia of chronic renal failure in South Africa

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dc.contributor.authorSwanepoel, C. R.en_ZA
dc.contributor.authorMoosa, M. R.en_ZA
dc.contributor.authorRowland, G. F.en_ZA
dc.contributor.authorMeyers, A. M.en_ZA
dc.contributor.authorBotha, B. P.en_ZA
dc.contributor.authorSmart, A. J.en_ZA
dc.contributor.authorGoodman, R.en_ZA
dc.contributor.authorSchall, R.en_ZA
dc.contributor.authorKeogh, H. J.en_ZA
dc.contributor.authorMerrifield, E. H.en_ZA
dc.date.accessioned2011-03-18T14:57:10Z
dc.date.available2011-03-18T14:57:10Z
dc.date.issued1996
dc.descriptionCITATION: Swanepoel, C. R. et al. 1996. Clinical experience with Repotin, a locally produced recombinant human erythropoietin, in the treatment of anaemia of chronic renal failure in South Africa. South African Medical Journal, 86(10):1266-1269.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractObjective. To evaluate the efficacy and safety of Repotin, a locally produced recombinant human erythropoietin (rHuEPO), in the treatment of the anaemia of chronic renal failure (ACRF). Design. The study consisted of two multicentre non-randomised open stages. Setting. Renal units at several teaching hospitals in South Africa. Participants. Haemodialysis patients with haemoglobin (Hb) levels less than 8.0 g/dl were recruited. The first stage examined 26 patients during 12-week period in which the dose of intravenous rHuEPO was adjusted according to haematological response. In the second stage 27 patients were stabilised with intravenous rHuEPO and then maintained at a Hb level above 8.0 g/dl by subcutaneous administration for up to 1 year. Outcome measures. In both stages, outcome was measured by clinical examination, blood pressure, full haematological parameters and blood chemistry. Results. In stage 1, all patients responded to therapy with a statistically significant increase in Hb from geometric means of 6.28 g/dl to 8.50 g/dl (geometric SDs of 1.17 and 1.20 respectively). The doses used ranged from 25 IU to 125 IU/kg (average 47.1). In the second stage, Hb levels reached a mean of 8.06 g/dl (SD 0.9) and were maintained at target range with an average dose of 55.5 IU/kg three times a week. Apart from changes in serum iron, ferritin (associated with increased haematopoiesis) and potassium, there were no significant alterations in blood chemistry. The incidence of adverse events reported during the 12-month second stage was no greater than that reported for other forms of rHuEPO therapy. Conclusion. Repotin is a safe and effective rHuEPO preparation for the treatment of ACRF.
dc.description.versionPublisher’s version
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7236
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.titleClinical experience with Repotin, a locally produced recombinant human erythropoietin, in the treatment of anaemia of chronic renal failure in South Africaen_ZA
dc.typeArticle
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