Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria

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dc.contributor.authorVan Zyl, Winschau F.en_ZA
dc.contributor.authorDeane, Shelly M.en_ZA
dc.contributor.authorDicks, Leon Milner Theodore, 1961-en_ZA
dc.date.accessioned2020-11-09T10:17:17Z
dc.date.available2020-11-09T10:17:17Z
dc.date.issued2020
dc.descriptionCITATION: Van Zyl, W. F., Deane, S. M. & Dicks, L. M. T. 2020. Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria. Gut Microbes, 12(1):e1831339, doi:10.1080/19490976.2020.1831339.
dc.descriptionThe original publication is available at https://www.tandfonline.com
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund
dc.description.abstractGastrointestinal (GI) diseases, and in particular those caused by bacterial infections, are a major cause of morbidity and mortality worldwide. Treatment is becoming increasingly difficult due to the increase in number of species that have developed resistance to antibiotics. Probiotic lactic acid bacteria (LAB) have considerable potential as alternatives to antibiotics, both in prophylactic and therapeutic applications. Several studies have documented a reduction, or prevention, of GI diseases by probiotic bacteria. Since the activities of probiotic bacteria are closely linked with conditions in the host’s GI-tract (GIT) and changes in the population of enteric microorganisms, a deeper understanding of gut-microbial interactions is required in the selection of the most suitable probiotic. This necessitates a deeper understanding of the molecular capabilities of probiotic bacteria. In this review, we explore how probiotic microorganisms interact with enteric pathogens in the GIT. The significance of probiotic colonization and persistence in the GIT is also addressed.en_ZA
dc.description.urihttps://www.tandfonline.com/doi/full/10.1080/19490976.2020.1831339
dc.description.versionPublisher's version
dc.format.extent25 pages : illustrations
dc.identifier.citationVan Zyl, W. F., Deane, S. M. & Dicks, L. M. T. 2020. Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria. Gut Microbes, 12(1):e1831339, doi:10.1080/19490976.2020.1831339
dc.identifier.issn1949-0984 (online)
dc.identifier.issn1949-0976 (print)
dc.identifier.otherdoi:10.1080/19490976.2020.1831339
dc.identifier.urihttp://hdl.handle.net/10019.1/108924
dc.language.isoen_ZAen_ZA
dc.publisherTaylor and Francis
dc.rights.holderAuthors retain copyright
dc.subjectBacterial infectionsen_ZA
dc.subjectBacterial diseases -- Molecular aspectsen_ZA
dc.subjectPathogenic bacteriaen_ZA
dc.subjectDisease germsen_ZA
dc.subjectProbioticsen_ZA
dc.subjectGastrointestinal system -- Diseasesen_ZA
dc.subjectGastrointestinal system -- Microbiologyen_ZA
dc.subjectIntestines -- Microbiologyen_ZA
dc.subjectLactobacillusen_ZA
dc.subjectGastrointestinal tracten_ZA
dc.subjectGITen_ZA
dc.subjectProbiotic supplementsen_ZA
dc.subjectLactic acid bacteria (LAB)en_ZA
dc.subjectGastrointestinal systemen_ZA
dc.titleMolecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteriaen_ZA
dc.typeArticleen_ZA
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