Simian immunodeficiency viruses (SIVs) from eastern and southern Africa: Detection of a SIVagm variant from a chacma baboon

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dc.contributor.authorVan Rensburg E.J.
dc.contributor.authorEngelbrecht S.
dc.contributor.authorMwenda J.
dc.contributor.authorLaten J.D.
dc.contributor.authorRobson B.A.
dc.contributor.authorStander T.
dc.contributor.authorChege G.K.
dc.date.accessioned2011-05-15T16:16:58Z
dc.date.available2011-05-15T16:16:58Z
dc.date.issued1998
dc.description.abstractSimian immunodeficiency viruses (SIVs) have been shown to infect many Old World African primate species. Thus far, no work has been published on southern African primates. In this study we investigated the genetic diversity between SIV strains from Kenyan and South African vervets (Cercopithecus aethiops pygerythrus). We amplified and sequenced a 1113 bp region of the env gene. Phylogenetic analysis of these sequences showed that all strains clustered with members of the vervet subgroup of SIVagm. The SIVs from South African vervets differed by 7% from each other and by 8-14% from the Kenyan SIV strains, while the Kenyan SIV strains differed by 10-21% from SIVagm of other east African vervets. We also isolated and sequenced, for the first time, a SIV strain from a healthy chacma baboon (Papio ursinus), caught in South Africa. Phylogenetic analysis of the env region showed the virus to be closely related to the South African vervet SIV strains, while analysis of its pol region confirmed the virus to be a SIVagm variant.
dc.description.versionArticle
dc.identifier.citationJournal of General Virology
dc.identifier.citation79
dc.identifier.citation7
dc.identifier.issn00221317
dc.identifier.urihttp://hdl.handle.net/10019.1/14018
dc.subjectafrica
dc.subjectarticle
dc.subjectbaboon
dc.subjectenvelope gene
dc.subjectgene amplification
dc.subjectgene sequence
dc.subjectmonkey
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectphylogeny
dc.subjectpriority journal
dc.subjectsimian immunodeficiency virus
dc.subjectAmino Acid Sequence
dc.subjectAnimals
dc.subjectBase Sequence
dc.subjectCercopithecus aethiops
dc.subjectDNA, Viral
dc.subjectGene Products, env
dc.subjectKenya
dc.subjectMolecular Sequence Data
dc.subjectPhylogeny
dc.subjectSequence Homology, Amino Acid
dc.subjectSimian Acquired Immunodeficiency Syndrome
dc.subjectSimian immunodeficiency virus
dc.subjectSouth Africa
dc.subjectVariation (Genetics)
dc.subjectCercocebus
dc.subjectCercopithecus
dc.subjectCercopithecus aethiops pygerythrus
dc.subjectPapio hamadryas
dc.subjectPapio ursinus
dc.subjectPrimates
dc.subjectRNA viruses
dc.subjectSimiae
dc.subjectSimian immunodeficiency virus
dc.titleSimian immunodeficiency viruses (SIVs) from eastern and southern Africa: Detection of a SIVagm variant from a chacma baboon
dc.typeArticle
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